Neurofibrillary tangles

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Laboratory for Neuropathology, Department of Imaging and Pathology, KU Leuven (University of Leuven), Leuven, Belgium;Leuven Brain Institute (LBI), KU Leuven (University of Leuven), Leuven, Belgium;Department of Imaging & Pathology, UZ Leuven (University Hospital Leuven), Leuven, Belgium. (1)
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Department of Pediatrics, University of Groningen, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands (1)
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School of Biosciences, University of Birmingham, UK (1)
F.M Kirby Neurobiology Center, Boston Children’s Hospital, Boston, MA, USA. Harvard Medical School, Boston, MA, USA (1)
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Transcription profiling of human neurons with and without neurofibriallary tangles from Alzheimer's patients

Alzheimer's Disease (AD) is a devastating neurodegenerative disorder affecting approximately 4 million people in the U.S. alone. AD is characterized by the presence of senile plaques and neurofibrillary tangles in cortical regions of the brain. These pathological markers are thought to be responsi...

ORGANISM(S): Homo sapiens

2009-09-05 | E-GEOD-4757 | biostudies-arrayexpress

Phosphorylated Tau Interactome in the Human Alzheimers Disease Brain

Accumulation of phosphorylated tau is a key pathological feature of Alzheimers disease. Phosphorylated tau accumulation causes synaptic impairment, neuronal dysfunction and formation of neurofibrillary tangles. The pathological actions of phosphorylated tau are mediated by surrounding neuronal prote...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2020-04-17 | MSV000085305 | MassIVE

The proteome of granulovacuolar degeneration and neurofibrillary tangles in Alzheimer’s disease

By combining immunohistochemistry (IHC) and laser microdissection (LMD) we isolated neurons with GVD and those bearing tangles separately from human post-mortem AD hippocampus (n=12) using their typical markers casein kinase (CK)1δ and phosphorylated tau (AT8). Control neurons were isolated from cog...

ORGANISM(S): Homo sapiens (Human)

2021-09-09 | PXD023199 | Pride

Alzheimer’s disease: neurofibrillary tangles (Rogers-3U24NS043571-01S1)

ORGANISM(S): Homo sapiens

2006-05-02 | GSE4757 | GEO

Genes associated with the progression of neurofibrillary tangles in Alzheimer's disease

PRJNA544416 | ENA

Distinct transcriptomic responses to Ab plaques, neurofibrillary tangles, and APOE in Alzheimer’s disease

PRJNA942219 | ENA

Early axonopathy preceding neurofibrillary tangles in mutant tau transgenic mice.

Not available

S-EPMC1959508 | biostudies-literature

Homo sapiens

Alzheimer’s disease: neurofibrillary tangles (Rogers-3U24NS043571-01S1)

PRJNA95567 | ENA

Identification of septins in neurofibrillary tangles in Alzheimer's disease.

Not available

S-EPMC1853406 | biostudies-literature

Genes associated with the progression of neurofibrillary tangles in Alzheimer's disease

Transcriptome analysis of post-mortem brain tissue specimens from three brain regions (BRs), entorinal, temporal and frontal cortices, of 71 Japanese brain-donor subjects to identify genes relevant to the expansion of neurofibrillary tangles. In total, 213 brain tissue specimens (= 71 subjects × 3 B...

ORGANISM(S): Homo sapiens

2019-05-24 | GSE131617 | GEO

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