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MetabolomicsLoss of SPTSSA Impairs Mitochondrial Function and Neuronal Differentiation in SH-SY5Y Neuroblastoma Cells
Sphingolipids are bioactive membrane and signaling lipids that not only shape cellular architecture but also orchestrate a network of interconnected metabolic pathways. Their core building blocks, sphingoid bases, are synthesized by the serine palmitoyltransferase (SPT) complex. At its core, the SPT...
2026-10-09 | MTBLS15875 | MetaboLights
GenomicsAPOE4 disrupts the central dogma by arresting neuronal proteome dynamics
APOE4 disrupts the central dogma by arresting neuronal proteome dynamics
PRJNA1494916 | ENA
TranscriptomicsAPOE4 disrupts the central dogma by arresting neuronal proteome dynamics
Apolipoprotein E4 (APOE4), the strongest genetic risk factor for late-onset Alzheimer's disease, promotes neuronal dysfunction through incompletely understood mechanisms. Here, we integrated transcriptomic, translatomic, and proteomic profiling of isogenic human iPSC-derived APOE3 and APOE4 neurons ...
ORGANISM(S): Homo sapiens 
2026-09-28 | GSE338530 | GEO
ProteomicsA quantitative map of proteome dynamics during neuronal differentiation
Neuronal differentiation is a multistep process that shapes and re-shapes neurons by progressing through several typical stages, including axon outgrowth, dendritogenesis and synapse formation. To systematically profile protein expression during neuronal differentiation we have used cultured hippoca...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-01-17 | PXD005031 | Pride
Adhesion molecules Adhesion molecule Stable isotope dimethyl labeling Ncam1 Mass spectrometry Neuronal differentiation Dendrite outgrowth Quantitative proteomics Proteome Neuronal development 
ProteomicsThe Aged Neuronal Aggregome Identified by BONCAT
Aggregating neuronal proteins. The identification of neuronal proteins contributing to aged protein aggregates was enabled by labeling the neuronal proteome with BONCAT technology, enrichment of insoluble protein aggregates, and affinity enrichment for the tagged proteins.
ORGANISM(S): Mus musculus (Mouse) 
2025-11-07 | PXD066053 | Pride
Boncat Aggregates Neurons Aggregome 
UnknownChaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.
Not available
S-EPMC8152331 | biostudies-literature
TranscriptomicsTranscription profiling and proteomic of mouse early embryonic brain development
Embryonic mouse brain development involves a sequential differentiation of multipotent progenitor cells into neurons and glia. Using microarrays and large 2-D electrophoresis, we investigated the transcriptome and proteome of mouse brains at embryonic days 9.5, 11.5 and 13.5. During this development...
ORGANISM(S): Mus musculus 
2008-06-19 | E-GEOD-8091 | biostudies-arrayexpress
ProteomicsDon’t die like me: Which proteins are responsible for the selective neuronal vulnerability within the substantia nigra?
A hallmark of Parkinson’s disease is the specific degeneration of dopaminergic neurons in the substantia nigra pars compacta. Interestingly, not all of these neurons are equally affected. Studies revealed that neurons located more ventrally within the substantia nigra pars compacta have a higher pre...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD037696 | Pride
Neurons Mass spectrometry Proteomic Selective neuronal vulnerability Substantia nigra 
TranscriptomicsRNA localization is a key determinant of neurite-enriched proteome - RNAseq
RNA localization and local translation are important biological processes that underlie establishment of body axis, cell migration and synaptic plasticity. However, it is unclear to which extent mRNA localization contributes toward local proteome and how much of protein localization is achieved via ...
ORGANISM(S): Mus musculus 
2017-07-23 | E-MTAB-4978 | biostudies-arrayexpress
UnknownNeuronal activity regulates the nuclear proteome to promote activity-dependent transcription.
Not available
S-EPMC8504181 | biostudies-literature
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