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Compound-Induced Neuroplasticity Without Immediate Early Gene Activation
In Alzheimer's disease (AD), early deficits in learning and memory are a consequence of synaptic modification which are likely induced by toxic beta-amyloid oligomers (dAbeta). To identify molecular targets downstream of dAbeta binding we prepared synaptoneurosomes from frontal cortex of control a...
ORGANISM(S): Homo sapiens 
See "Akula et al., Molecular Psychiatry in Press". RNA-sequencing (RNA-seq) is a powerful technique to investigate the complexity of gene expression in the human brain. We used RNA-seq to survey the brain transcriptome in high-quality post-mortem dorsolateral prefrontal cortex from 11 indi...
ORGANISM(S): Homo sapiens 
Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin
Mutation of brain aromatase impairs behavior and neuroplasticity in adult zebrafish
TGF-β and IL-4+IL-13 induce neuroplasticity in an in vitro model of hPSC-derived sensory neurons
Cortical atrophy and dysfunction are hallmarks of many neuropsychiatric diseases including depression, post-traumatic stress disorder (PTSD), and addiction. Psychoplastogens are small molecules with the potential to rapidly rescue these structural and functional deficits, leading to sustained therap...
ORGANISM(S): Mus musculus 
2025-05-10 | GSE277053 | GEO
Asthma is a chronic inflammatory disease of the airways characterized by airway hyperresponsiveness. Recent studies using mouse models, bronchial biopsies of asthma patients, and lung tissue of patients with fatal asthma have implicated neuroplasticity as a pathological feature of severe asthma, pos...
ORGANISM(S): Homo sapiens 
2026-02-13 | GSE307973 | GEO
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