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ProteomicsThe ubiquitin ligase Ariadne-1 regulates NSF for neurotransmitter release
The aim of the present project was to identify putative substrates of Ariadne-1 (Ari-1), an essential E3 ubiquitin-ligase, in Drosophila heads. For that purpose we combined an in vivo ubiquitin biotinylation strategy termed bioUb with label free mass spectrometry analysis. In brief, BioUb strategy r...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-02-09 | PXD022701 | Pride
Synapse E3 ubiquitin ligase Neurotransmitter release Ubiquitination Ariadne-1 Drosophila Nsf 
GenomicsAnalysis of a long noncoding RNAs that modulate neurotransmitter release
Analysis of a long noncoding RNAs that modulate neurotransmitter release
PRJNA542653 | ENA
ProteomicsTTC33 forms a complex with WDR61 and PHF5A to recruit factors relevant to genomic integrity 2/2
The functions of many human proteins remain unknown, highlighting major gaps in our understanding of cellular biology. TTC33 is an evolutionarily conserved tetratricopeptide repeat (TPR) protein expressed across human tissues, whose molecular role is not defined. Here we identify the TTC33 partners ...
ORGANISM(S): Homo sapiens (Human) 
2026-07-13 | PXD043138 | Pride
Phf5a and ttc33 form a vertebrate-specific novel complex coined ttc33-associated network (tan) which together with ccdc97 regulate levels of mrnas that mediate neurotransmitter release Wdr61 
GenomicsCross-Platform Validation of Neurotransmitter Release Impairments in Schizophrenia Patient-Derived NRXN1-Mutant Neurons
Cross-Platform Validation of Neurotransmitter Release Impairments in Schizophrenia Patient-Derived NRXN1-Mutant Neurons
PRJNA713833 | ENA
UnknownGenetic disorders of neurotransmitter release machinery.
Not available
S-EPMC10102358 | biostudies-literature
ProteomicsCalcium-triggered (de)ubiquitination events in synapses
Neuronal communication relies on neurotransmitter release from synaptic vesicles (SVs), whose dynamics are controlled by Ca2+-dependent pathways, as many thoroughly studied phosphorylation cascades. However, little is known about other post-translational modifications, as ubiquitination. To address ...
ORGANISM(S): Homo Sapiens Rattus Norvegicus 
PXD053470 | panorama
TranscriptomicsGeneChip expression profiling of Glud1 (glutamate dehydrogenase 1) transgenic mice
Glud1 (glutamate dehydrogenase 1) transgenic mice release more excitatory neurotransmitter glutamate to synaptic cleft throughout lifespan and show signs of accelerated aging. Here we compared transcriptomic profiles of these animals to their wild-type counterparts. The hippocampus was used for the ...
ORGANISM(S): Mus musculus 
2010-07-12 | E-GEOD-11419 | biostudies-arrayexpress
TranscriptomicsCross-Platform Validation of Neurotransmitter Release Impairments in Schizophrenia Patient-Derived NRXN1-Mutant Neurons
Heterozygous NRXN1 deletions constitute the most prevalent currently known single-gene mutation associated with schizophrenia, and predispose to multiple other neurodevelopmental disorders. Previous studies showed that engineered heterozygous NRXN1 deletions impaired neurotransmitter release in huma...
ORGANISM(S): Homo sapiens Mus musculus 
2021-03-12 | GSE168762 | GEO
UnknownRe-examining how complexin inhibits neurotransmitter release.
Not available
S-EPMC4040926 | biostudies-literature
UnknownStrikingly different neurotransmitter release strategies in dopaminergic subclasses.
Not available
S-EPMC12707814 | biostudies-literature
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