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ProteomicsComparative quantitative proteomic analysis of melanoma subtypes, nevus-associated melanoma, and corresponding nevi
A substantial part of cutaneous malignant melanomas develops from benign nevi. However, the precise molecular events driving the transformation from benign to malignant melanoma are not well understood. We used laser microdissection and mass spectrometry to analyze the proteomes of melanoma subtypes...
ORGANISM(S): Homo sapiens (Human) 
2024-01-28 | PXD044107 | Pride
Human Nevus-associated melanoma Proteomics Microdissection Skin cancer Skin Melanoma subtypes Ffpe Nevi Malignant melanoma 
UnknownPrognostic Value of Nevus-Associated Melanoma in Patients with Melanoma.
Not available
S-EPMC11976787 | biostudies-literature
UnknownThe Association of Nevus-Associated Melanoma with Common or Dysplastic Melanocytic Nevus: A Systematic Review and Meta-Analysis.
Not available
S-EPMC9913707 | biostudies-literature
TranscriptomicsExpression data from 7 Human Melanomas
Melanocytes within benign human nevi are the paradigm for tumor suppressive senescent cells in a pre-malignant neoplasm. These cells typically contain mutations in either the BRAF or N-RAS oncogene and express markers of senescence, including p16. However, a nevus can contain 10s to 100s of thousand...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-46817 | biostudies-arrayexpress
UnknownClinical benefit with tebentafusp in a patient with GNAQ mutant metastatic blue nevus-associated melanoma.
Not available
S-EPMC11574454 | biostudies-literature
UnknownPolymorphisms in nevus-associated genes MTAP, PLA2G6, and IRF4 and the risk of invasive cutaneous melanoma.
Not available
S-EPMC3266856 | biostudies-literature
TranscriptomicsTranscription profiling of human common melanocytic nevi, radial and vertical growth phase melanomas, melanoma metastases and dysplastic nevi
Despite malignant cutaneous melanoma is relatively rare compared to other skin cancers, it is still responsible for 80% of all skin cancer-related deaths. To identify molecular signatures of melanoma progression, excisional biopsies from 18 common melanocytic nevi (CMN), 8 primary radial growth phas...
ORGANISM(S): Homo sapiens 
2009-10-10 | E-GEOD-12391 | biostudies-arrayexpress
GenomicStudy of Melanoma Risk in Australia and the United Kingdom

The results from a small number of melanoma GWAS have been published. Initial studies identified several pigmentation- and nevus-associated loci that mediate an effect on melanoma risk, however, these studies were somewhat limited in that sample number (hence power) was low, they used first-gener...

phs000519 | dbGaP
UnknownChoroidal Nevus Features Associated with Subspecialty Referral.
Not available
S-EPMC10823039 | biostudies-literature
GenomicA Novel Recurrent Mutation in MITF Predisposes to Familial and Sporadic Melanoma

We conducted whole-genome sequencing of probands from several melanoma families, identifying one individual carrying a novel germline variant (c.G1075A, NM_000248.3; p.E318K, NP_000239.1; rs149617956) in the melanoma lineage-specific oncogene MITF. While the variant cosegregated with melanoma in ...

phs000419 | dbGaP
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