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TranscriptomicsNFAT-mediated gene expression response to LPS in murine dendritic cells and macrophages
This SuperSeries is composed of the following subset Series: GSE15718: Gene expression in dendritic cells stimulated with LPS in conditions allowing or inhibiting NFAT activation GSE15720: Apoptosis genes specifically modulated by NFAT in LPS-activated dendritic cells GSE15721: Gene expression in ma...
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-15759 | biostudies-arrayexpress
TranscriptomicsGene expression in macrophages stimulated with LPS in conditions allowing or inhibiting NFAT activation
Macrophages and dendritic cells (DCs) differently contribute to the generation of coordinated immune system responses against infectious agents. They interact with microbes through germline-encoded pattern-recognition receptors (PRRs), which recognize molecular patterns expressed by various microorg...
ORGANISM(S): Mus musculus 
2010-03-04 | E-GEOD-15721 | biostudies-arrayexpress
TranscriptomicsWnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl
Although Bcr-Abl kinase inhibitors have proven effective in the treatment of chronic myeloid leukemia (CML), they generally fail to completely eradicate Bcr-Abl+ leukemia cells. To identify genes whose inhibition sensitizes Bcr-Abl+ leukemias to killing by Bcr-Abl inhibitors, we performed an RNAi-ba...
ORGANISM(S): Homo sapiens 
2010-07-15 | E-GEOD-21499 | biostudies-arrayexpress
TranscriptomicsNFAT transcriptional activity is associated with metastatic capacity in colon cancer
Colorectal carcinoma is the third leading cause of cancer-related death in the United States. In order to understand the mechanism/signaling pathways responsible for invasion, migration and metastasis in colorectal cancer, we developed an integrative and comparative genetic approach to infer transcr...
ORGANISM(S): Homo sapiens 
2014-10-21 | E-GEOD-38832 | biostudies-arrayexpress
TranscriptomicsApoptosis genes specifically modulated by NFAT in LPS-activated dendritic cells
Dendritic cells (DCs) are a special class of leukocytes able to activate both innate and adaptive immune responses. They interact with microbes through germline-encoded pattern-recognition receptors (PRRs), which recognize molecular patterns expressed by various microorganisms. Upon antigen binding,...
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-15720 | biostudies-arrayexpress
TranscriptomicsGene expression in dendritic cells stimulated with LPS in conditions allowing or inhibiting NFAT activation
Interleukin-2 (IL-2) is one of the molecules produced by mouse dendritic cells (DCs) after stimulation by Toll like receptor (TLR) agonists. By analogy with the events following T-cell receptor (TCR) engagement leading to IL-2 production we have observed that DC stimulation with lipopolysaccharide (...
ORGANISM(S): Mus musculus 
2010-03-04 | E-GEOD-15718 | biostudies-arrayexpress
GenomicsDirect regulation of T cell exhaustion by NFAT [ChIP-Seq]
During persistent antigen stimulation, CD8+ cytolytic T cells (CTL) show a gradual decrease in effector function, or “exhaustion”, which impairs the immune response to tumors and infections. Here we show that NFAT, a transcription factor with an established role in T cell activation, in parallel con...
ORGANISM(S): Mus musculus 
2015-02-13 | E-GEOD-64407 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse MyD88-deficient bone marrow-derived macrophages treated with Zymosan
Innate immune pattern recognition receptors play critical roles in pathogen detection and initiation of antimicrobial responses. We and others have previously demonstrated the importance of the beta-glucan receptor Dectin-1 in the recognition of pathogenic fungi by macrophages and dendritic cells, a...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6376 | biostudies-arrayexpress
ProteomicsA longer isoform of Stim1 is a negative SOCE regulator but increases cAMP modulated NFAT signaling
Alternative splicing is a potent modifier of protein function. Stromal interaction molecule 1 (Stim1) is the essential activator of store-operated Ca2+ entry (SOCE) triggering activation of transcription factors. Here, we characterize Stim1A, a splice variant with an additional 31 amino acid domain ...
ORGANISM(S): Homo sapiens (Human) 
2021-11-11 | PXD028974 | Pride
Orai Pip2 Splicing Nfat Pde8 
TranscriptomicsThe dependence on NFAT levels discriminates conventional T cells from Foxp3 expressing regulatory cells
In this study, we used microarrays to investigate the gene expression program in conventional T cells, nTreg and conventional T cells treated with TGFbeta (iTreg) from wild-type mice and and mice having NFAT1/NFAT2 double-deficient (DKO) T cells. CD4+CD25- and CD4+CD25+ T cells were isolated by MACS...
ORGANISM(S): Mus musculus 
2012-10-15 | E-MEXP-3687 | biostudies-arrayexpress
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