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TranscriptomicsGlobal Gene Expression in Deceased Donor Liver Transplantation with Ischemic Preconditioning
The clear benefits of ischemic preconditioning (IPC) in reducing ischemia reperfusion injury (IRI) remain indistinct in human liver transplantation. To further understand the mechanistic aspects of IPC in human deceased donor liver transplantation (DDLT), we performed microarray analyses to determin...
ORGANISM(S): Homo sapiens 
2010-05-20 | E-GEOD-15480 | biostudies-arrayexpress
TranscriptomicsThe relationship between the gene expression profile in the synovium of RA patients at baseline and the clinical response to infliximab treatment
Background: Although the use of TNF inhibitors has fundamentally changed the way rheumatoid arthritis (RA) is treated, not all patients respond well. It is desirable to facilitate the identification of responding and non-responding patients prior to treatment, not only to avoid unnecessary treatment...
ORGANISM(S): Homo sapiens 
2010-04-28 | E-GEOD-21537 | biostudies-arrayexpress
TranscriptomicsBraveheart is a long non-coding RNA necessary for cardiac lineage commitment
Purpose: Long non-coding RNAs (lncRNAs) display development-specific gene expression patterns, yet we know little about their precise roles in lineage commitment. Here, we discover a novel mammalian heart-associated lncRNA, AK143260, necessary for cardiac lineage specification. Methods: Gene express...
ORGANISM(S): Mus musculus 
2013-01-30 | E-GEOD-39656 | biostudies-arrayexpress
MetabolomicsCysteamine-bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis
Nephropathic cystinosis is a severe monogenic kidney disorder caused by mutations in CTNS, encoding the lysosomal transporter cystinosin, resulting in lysosomal cystine accumulation. The sole treatment, cysteamine, slows down the disease progression, but does not correct the established renal proxim...
2021-06-24 | MTBLS2538 | MetaboLights
TranscriptomicsThe chromatin protein Nupr1 regulates RelB-dependent NF-kB events necessary for pancreatic cancer development
The objective of this study was to elucidate the role of Nupr1 in pancreatic tumorigenesis. Using the Pdx-1-cre;LSL-KrasG12D mouse as model we discovered that, in contrast to KrasG12D pancreas that develop multiple foci of pancreatic intraepithelial neoplasia (PanIN), KrasG12D;Nupr1KO pancreas were ...
ORGANISM(S): Homo sapiens 
2012-02-01 | E-GEOD-35463 | biostudies-arrayexpress
TranscriptomicsCell cannibalism, a cell-death process driven by the Transforming Growth Factor-M-NM-2 and the Nuclear Protein 1, opposes to metastasis in pancreatic cancer
Pancreatic adenocarcinoma (PDAC) is an extremely deadly disease for which all treatments available have failed to improve life expectancy significantly. This may be explained by the high metastatic potential of PDAC cells, which results from their physiological dedifferentiation towards a mesenchyma...
ORGANISM(S): Homo sapiens 
2012-06-17 | E-GEOD-38772 | biostudies-arrayexpress
TranscriptomicsA Genetic-to-Epigenetic Crosstalk Plays a Pivotal Role in the Promotion of KrasG12D-Induced Senescence and PanIN formation
Nupr1 is a chromatin protein which cooperates with KrasG12D to induce PanIN formation in mice, though the molecular mechanisms underlying this effect remain to be fully characterized. In the current study, we find that Nupr1 acts as a gene modifier of the effect of KrasG12D-induced senescence by reg...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-45232 | biostudies-arrayexpress
TranscriptomicsExpression data of human perirenal adipose tissue-derived mesenchymal stem cells cultured under various conditions
Human mesenchymal stem cells (MSC) derived from perirenal adipose tissue (PV) of living kidney donors were cultured under various conditions, namely (1) control (medium+foetal bovine serum(FBS)) or (2) control (medium+heat-inactivated FBS); (3) with mixed-lympohocyte reactions (MLR) in transwell cul...
ORGANISM(S): Homo sapiens 
2010-10-01 | E-GEOD-18662 | biostudies-arrayexpress
TranscriptomicsCorrection of the FSHD myoblast differentiation defect by fusion with healthy myoblasts
Facioscapulohumeral dystrophy (FSHD) is a neuromuscular disease characterized by progressive asymmetric muscle weakness. Myoblasts isolated from FSHD muscles exhibit morphological differentiation defects and show a distinct transcription profile. These abnormalities may be linked to the muscle weakn...
ORGANISM(S): Homo sapiens 
2015-08-17 | E-MTAB-3658 | biostudies-arrayexpress
TranscriptomicsNuclear protein (Nupr)-1 is required for pancreatic adenocarcinoma development in Pdx1-cre;LSL-KrasG12D;Ink4a/Arffl/fl mice
Nuclear Protein 1 (Nupr1) is a major actor of the cell stress response required for KrasG12D-driven formation of pancreatic intraepithelial neoplastic (PanINs) lesions in mice. We investigated the impact of Nupr1-depletion on the development and biology of murin pancreatic adenocarcinomas (PDAC) in ...
ORGANISM(S): Mus musculus 
2012-12-16 | E-GEOD-42322 | biostudies-arrayexpress
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