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GenomicsDifferential gene expression in immortalised fibroblasts derived two independent Nestor Guillermo Progeria Syndrome (NGPS) patients, compared to immortalised fibroblasts of an healthy individual
Differential gene expression in immortalised fibroblasts derived two independent Nestor Guillermo Progeria Syndrome (NGPS) patients, compared to immortalised fibroblasts of an healthy individual
PRJNA1122124 | ENA
TranscriptomicsDifferential gene expression in immortalised fibroblasts derived two independent Nestor Guillermo Progeria Syndrome (NGPS) patients, compared to immortalised fibroblasts of an healthy individual
Progeria syndromes are very rare, incurable premature aging conditions recapitulating most aging features. Through a whole genome, multiparametric CRISPR anti-aging screen,we identified 43 new genes that can reverse multiple aging phenotypes in progeria. The screen was implemented in fibroblasts fro...
ORGANISM(S): Homo sapiens 
2024-10-18 | GSE269484 | GEO
ProteomicsNext Generation Protein Sequencing
NGPS is a method for de-novo, full-length protein sequencing in high throughput. The method is based on cleavage of the protein at semi-random sites by microwave-assisted acid hydrolysis (MAAH), enrichment of LC-MS/MS amenable peptides from the hydrolysate by solid-phase-extraction, LC-MS/MS analysi...
ORGANISM(S): Bos taurus (Bovine) Equus caballus (Horse) 
2017-04-03 | PXD003804 | Pride
Full length Maah De-novo Ngps Microwave 
TranscriptomicsNF-κB activation impairs somatic cell reprogramming in ageing [NGPS_iPSCs]
Transcriptional profiling of human control and Néstor-Guillermo Progeria Syndrome (NGPS) fibroblasts and induced pluripotent stem cells (iPSCs). Somatic cell reprogramming involves rejuvenation of adult cells and relies on the ability to erase age-associated molecular marks. Accordingly, reprogramm...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-65170 | biostudies-arrayexpress
TranscriptomicsNF-κB activation impairs somatic cell reprogramming in ageing [MSCs]
Transcriptional profiling of human control and Néstor-Guillermo Progeria Syndrome (NGPS) mesenchymal stem cells (MSCs). Somatic cell reprogramming involves rejuvenation of adult cells and relies on the ability to erase age-associated molecular marks. Accordingly, reprogramming efficiency declines w...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-65172 | biostudies-arrayexpress
UnknownCo-delivery of glycyrrhizin and doxorubicin by alginate nanogel particles attenuates the activation of macrophage and enhances the therapeutic efficacy for hepatocellular carcinoma.
Not available
S-EPMC6735516 | biostudies-literature
UnknownNext-generation probiotics - do they open new therapeutic strategies for cancer patients?
Not available
S-EPMC8855854 | biostudies-literature
UnknownThe BAF A12T mutation disrupts lamin A/C interaction, impairing robust repair of nuclear envelope ruptures in Nestor-Guillermo progeria syndrome cells.
Not available
S-EPMC9458464 | biostudies-literature
TranscriptomicsStochastic genome-nuclear lamina interactions: Modulating roles of Lamin A and BAF
The nuclear lamina (NL) is a filamentous layer lining the inner-nuclear-membrane (INM) that aids in the organization of the genome in large domains of low transcriptional activity. Recently, it was shown that the single-cell genome-NL interactions are much more dynamic than previously anticipated, w...
ORGANISM(S): Homo sapiens 
2014-02-15 | E-GEOD-55066 | biostudies-arrayexpress
UnknownA human progeria-associated BAF-1 mutation modulates gene expression and accelerates aging in C. elegans.
Not available
S-EPMC11574047 | biostudies-literature
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