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TranscriptomicsTranscription profiling of CD8+CD57+ T cells from healthy donors and HIV patients
Gene Array Analysis of CD8+ CD57+ T cells in HIV Patients. Gene expression patterns of CD8+CD57+ T cells from healthy donors and HIV patients were compared. Gene expression patterns of CD8+CD57- T cells and CD8+CD57+ T cells were compared.
ORGANISM(S): Homo sapiens 
2005-07-30 | E-MEXP-393 | biostudies-arrayexpress
ProteomicsUsing global proteomics to investigate the effect of IQDMA treatment on Leukemic forms of cutaneous T-cell lymphomas (L-CTCL) cells
Leukemic cutaneous T-cell lymphomas (L-CTCL) are lymphoproliferative disorders of skin-homing mature T-cells causing chronic inflammation, tissue destruction, severe infections and sepsis, all linked to poor quality of life and high mortality. Despite numerous sequencing efforts in L-CTCL, recurrent...
ORGANISM(S): Homo sapiens (Human) 
2022-10-06 | PXD035699 | Pride
Cutaneous t-cell lymphoma Kinases 
ProteomicsUsing global proteomics to investigate the effect of IQDMA treatment on Leukemic forms of cutaneous T-cell lymphomas (L-CTCL) cells
Leukemic cutaneous T-cell lymphomas (L-CTCL) are lymphoproliferative disorders of skin-homing mature T-cells causing chronic inflammation, tissue destruction, severe infections and sepsis, all linked to poor quality of life and high mortality. Despite numerous sequencing efforts in L-CTCL, recurrent...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035626 | Pride
Global proteomics Kinase Cutaneous t-cell lymphomas (l-ctcl) 
UnknownRegio-regular alternating diketopyrrolopyrrole-based D1-A-D2-A terpolymers for the enhanced performance of polymer solar cells.
Not available
S-EPMC9076513 | biostudies-literature
TranscriptomicsIdentification of beta-catenin-associated RNAs in myeloid leukaemia cells through RIP-seq
Myeloid cell lines (K562 and HEL) were treated overnight with CHIR99021 or a vehicle control (DMSO). CHIR99021 treatment inhibits GSK3B within the destruction complex functioning in Wnt/beta-catenin signalling pathway, thereby preventing beta-catenin degradation and promoting its stabilization. Foll...
ORGANISM(S): Homo sapiens 
2025-04-08 | E-MTAB-14675 | biostudies-arrayexpress
ProteomicsSecretome of LYN deficient HS-5 stroma cells
LYN kinase is a tyrosine kinase, that regulates cellular homeostasis in a context specific manner. Our group could show, that its expression in the leukemic microenvironment of chronic lymphocytic leukemia contributes to disease progression (Nguyen PH et al.; Cancer Cell; 2016). To analyze the effec...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD028855 | Pride
Lyn kinase Hs-5 Stroma Bmsc Secretome Multi-omics 
ProteomicsProteome / pYome of LYN deficient HS-5 stroma cells
LYN kinase is a tyrosine kinase, that regulates cellular homeostasis in a context specific manner. Our group could show, that its expression in the leukemic microenvironment of chronic lymphocytic leukemia contributes to disease progression (Nguyen PH et al.; Cancer Cell; 2016). To analyze the effec...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD030582 | Pride
Lyn kinase Hs-5 Stroma Bmsc Secretome Multi-omics 
ProteomicsDirected evolution of the multicopper oxidase laccase for cell surface proximity labeling and electron microscopy
Enzymes that oxidize aromatic substrates have shown utility in a range of cell-based technologies including live cell proximity labeling (PL) and electron microscopy (EM), but are associated with drawbacks such as the need for toxic H2O2. Here, we explore laccases as a novel enzyme class for PL and ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-12 | PXD062870 | Pride
Tmt Proximity labeling 
TranscriptomicsIGR_U985_CLL_EGR2_GE_STUDY_OB
Chronic lymphocytic leukemia (CLL), the most frequent adult leukemia in western countries, is a clonal accumulation of mature B-lymphocytes and its natural history is yet unclear. By using sequencing and cellular biology approaches on a cohort of CLL patient samples, we show here that acquired CLL m...
ORGANISM(S): Mus musculus 
2014-06-18 | E-MTAB-1764 | biostudies-arrayexpress
ProteomicsPreclinical Evaluation of seco-Duocarmycin SA in Aggressive Glioblastoma Cell Lines
Glioblastoma multiforme (GBM) is among the most lethal primary brain tumors and is characterized by significant cellular heterogeneity and resistance to conventional therapies. This study investigates the efficacy of seco-duocarmycin SA (seco-DSA), a novel DNA alkylating agent. Initial investiga-tio...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD061023 | Pride
Proof of concept Glioblastoma multiforme Resistance Cellular mechanisms Seco-dsa Duocarmycin Potency 
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