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ProteomicsGlycans on Non-Structural Protein 1 Prevent Premature T-cell Mediated Dengue Virus Clearance
Non-structural protein 1 (NS1) of dengue virus (DENV) harbours two conserved N-glycosylation sites at positions 130 and 207, whose biological roles have remained elusive. Using a clinically relevant mouse model of severe dengue, we showed that DENV that lacked N207 glycans on NS1 was significantly a...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD065422 | Pride
Dengue/glycosylation/pd-1/ns1/t-cell apoptosis. 
MetabolomicsAn ancient residue metabolomics-based method to distinguish use of closely related plant species in ancient pipes

Residues from ancient artifacts can help identify which plant species were used for their psychoactive properties, providing important information regarding the deep-time co-evolutionary relationship between plants and humans. However, relying on the presence or absence of one or several biomarke...

2020-07-21 | MTBLS890 | MetaboLights
ProteomicsStroke Recovery Dominated by Dysregulation of Complement System – A Longitudinal Proteomics Pathway Analysis
Post-stroke recovery is an ongoing process as the brain attempts to reverse or minimize ischemia- induced disturbances in multiple biological systems. Currently, the longitudinal profile of molecular changes in patients post-stroke is relatively unknown. We therefore aimed to characterise biological...
ORGANISM(S): Homo sapiens (Human) 
2020-08-31 | PXD015006 | Pride
Stroke Human Edta plasma Blood Q exactive hf 
UnknownNano-optogenetic engineering of CAR T cells for precision immunotherapy with enhanced safety.
Not available
S-EPMC8678207 | biostudies-literature
UnknownBioinspired total synthesis and human proteasome inhibitory activity of (-)-salinosporamide A, (-)-homosalinosporamide A, and derivatives obtained via organonucleophile promoted bis-cyclizations.
Not available
S-EPMC5546919 | biostudies-literature
ProteomicsDelineating the role of cooperativity in the design of potent PROTACs for BTK
Proteolysis targeting chimeras (PROTACs) are heterobifunctional small molecules that simultaneously bind to a target protein and an E3 ligase, thereby leading to ubiquitination and subsequent degradation of the target. They present an exciting opportunity to modulate proteins in a manner independent...
ORGANISM(S): Rattus rattus (Black rat) Homo sapiens (Human) 
2018-07-31 | PXD010606 | Pride
Tandem mass tag (tmt) Bruton’s tyrosine kinase (btk) Quantitative proteomics Proteolysis targeting chimera (protac) 
UnknownSpatial distribution of Taenia solium exposure in humans and pigs in the Central Highlands of Vietnam.
Not available
S-EPMC6168177 | biostudies-literature
ProteomicsAn Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells
Electrophilic compounds originating from nature or chemical synthesis have profound effects on immune cells. These compounds are thought to act by cysteine modification to alter the functions of immune-relevant proteins; however, our understanding of electrophile-sensitive cysteines in the human imm...
ORGANISM(S): Homo sapiens (Human) 
2024-02-12 | PXD049322 | Pride
Cysteine Activity-based protein profiling Birc3 Chemical proteomics Covalent electrophiles Protein degradation Human t cells Itk 
ProteomicsIntroducing the Sinclair Nanopig™ model: Preliminary genomic, proteomic, and hepatic CYP450 characterization for (bio)pharmaceutical safety assessment
The Nanopig™ model is an emerging non-rodent platform for (bio)pharmaceutical safety assessment, with potential advantages for translational research. Here, we report initial characterization results using whole genome sequencing (WGS) and tissue-based proteomics, focusing on drug metabolism and imm...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2025-10-08 | PXD069209 | Pride
Nanopig Tissue Plasma Lc-msms 
ProteomicsIntroducing the Sinclair Nanopig™ model: Preliminary genomic, proteomic, and hepatic CYP450 characterization for (bio)pharmaceutical safety assessment
he Nanopig™ model is an emerging non-rodent platform for (bio)pharmaceutical safety assessment, with potential advantages for translational research. Here, we report initial characterization results using whole genome sequencing (WGS) and tissue-based proteomics, focusing on drug metabolism and immu...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2025-10-08 | PXD068793 | Pride
Hepatic cyp450 Preclinical model Nanopig Whole genome sequencing Proteomics 
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