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ProteomicsSynergistically bifunctional magnetic beads enable efficient isolation of urine extracellular vesicles and downstream phosphoproteomic analysis
Capture of urinary EVs with different functionalized magnetic beads and analysis of their phosphoproteome
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD020573 | Pride
Human Phosphoproteomic Urine extracellular vesicles 
ProteomicsPhosphoproteins in extracellular vehicles as candidate markers for breast cancer
The state of protein phosphorylation can be a key determinant of cellular physiology such as early stage cancer, but the development of phosphoproteins from biofluids for disease diagnosis remains elusive. Here we demonstrate, for the first time, a strategy to isolate and identify phosphoproteins in...
ORGANISM(S): Homo sapiens (Human) 
2017-03-23 | PXD005214 | Pride
Plasma Extracellular vesicles Phosphoproteomics Biomarker 
ProteomicsDiscovery of Chirally-dependent Protein O-2-Hydroxyglutarylation
Mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 are common in multiple types of human cancer and cause accumulation of the oncometabolite D-2-hydroxyglutarate (D2HG), which promotes tumor progression by noncovalently inhibiting α-ketoglutarate–dependent enzymes. Here we discovered covalent O...
ORGANISM(S): Homo sapiens (Human) 
2026-03-18 | PXD072530 | Pride
D2hg L2hg Ptm O-2-hydroxyglutarylation 
TranscriptomicsSingle-cell and single-nucleus RNAseq of the human and mouse skeletal muscle across age
This study aims to characterize the diversity of cell types in human skeletal muscle across age using two complementary technologies: single-cell and single-nucleus sequencing, which provide a comprehensive coverage of cell types in the muscle. We leveraged the aforementioned datasets to study chang...
ORGANISM(S): Mus musculus 
2024-03-07 | E-MTAB-13874 | biostudies-arrayexpress
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