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ProteomicsProtein Contaminants Matter: Building Universal Protein Contaminant Libraries for DDA and DIA Proteomics
Mass spectrometry-based proteomics is challenged by the presence of contaminant background signals. In particular, protein contaminants from reagents and sample handling are often abundant and almost impossible to avoid, reducing the sensitivity, specificity and reproducibility of protein identifica...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2022-01-21 | MSV000088714 | MassIVE
ProteomicsBTN2A1 Targeting Reprograms M2-like Macrophages and TAMs via SYK and MAPK Signaling
Tumor-associated macrophages (TAMs), often adopting an immunosuppressive M2-like phenotype, correlate with unfavorable cancer outcomes. Our investigation unveiled elevated expression of the butyrophilin (BTN)2A1 in M2-like TAMs across diverse cancer types. We developed anti-BTN2A1 monoclonal antibod...
ORGANISM(S): Homo sapiens (Human) 
2024-09-02 | PXD055262 | Pride
Lc-msms Ap-ms Butyrophilin (btn)2a1 Reprogramming Mapk Immunosuppressive m2-like Syk Cancer 
ProteomicsProteomic profile of healthy human monocytes differentiated to macrophages with non-tumor or tumor cell-derived extracellular vesicles
To investigate the impact of tumor cell-derived extracellular vesicles on monocyte-macrophage differentiation, healthy monocytes were treated with EVs derived from two different pancreatic cancer cell lines and a non-tumoral pancreatic ductal epithelial cell line. Following differentiation to macrop...
ORGANISM(S): Homo sapiens (Human) 
2026-06-11 | PXD039439 | Pride
Lc-msms Monocytes Tumor-associated macrophages Extracellular vesicles Immunosuppression 
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