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MetabolomicsGut symbiotic bacteria-derived nicotinic acid regulates Bactrocera dorsalis reproduction

Depletion of gut commensal bacteria significantly reduced nicotinic acid (NA) levels in the hemolymph and ovaries of Bactrocera dorsalis, leading to impaired ovarian development. This inhibition was reversed by exogenous NA supplementation. We identified Enterobacter hormaechei as a key NA-produc...

2025-07-30 | MTBLS12798 | MetaboLights
MetabolomicsMicrobiome-produced nicotinic acid controls colon regional identity and injury susceptibility

Regional structure of the intestinal epithelium is critical for its function and is associated with the risk of specific gut diseases. However, how regionalization is established and how it influences disease susceptibility remains poorly understood. Here, we investigated the role of the gut micr...

2026-03-27 | MTBLS12063 | MetaboLights
TranscriptomicsTranscription profiling of Bordetella bronchiseptica RB50 nicotinic acid dose curve
B. bronchiseptica RB50 and a constitutive Bvg+ phase-locked mutant were grown at 37 degrees C in media containing a range of nicotinic acid concentrations.
ORGANISM(S): Bordetella bronchiseptica 
2006-03-31 | E-TABM-28 | biostudies-arrayexpress
ProteomicsN-Terminal Protein Sequencing by Nicotinic Acid Derivatization and MS Analysis
Most MS-based workflows for N-terminal protein sequence analysis rely on the modification of primary amines at the protein N-terminus and lysine residues, in many cases through dimethylation. However, incomplete dimethyl labeling and undesired side reactions have been reported previously and were al...
ORGANISM(S): Bos taurus (Bovine) Escherichia coli Equus caballus (Horse) 
2026-08-17 | PXD081064 | Pride
Protein sequencing Dimethylation N-terminomics Nicotinic acid N-terminal 
TranscriptomicsTranscription profiling of Bordetella pertussis GMT-1 nicotinic acid dose curve
B. pertussis GMT-1 and a constitutive Bvg+ phase-locked mutant were grown at 37 degrees C in media containing a range of nicotinic acid concentrations
ORGANISM(S): Bordetella pertussis 
2006-03-31 | E-TABM-29 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of 3 Bordetella bronchiseptica strains plus or minus nicotinic acid
Three B. bronchiseptica strains were grown at 37 degrees C in media containing or lacking nicotinic acid. Samples were harvested at mid-log phase and gene expression difference between the treated and untreated was measured for each strain.
ORGANISM(S): Bordetella bronchiseptica 
2005-12-31 | E-TABM-27 | biostudies-arrayexpress
TranscriptomicsDeep sequencing of endogenous mRNA from Caenorhabditis elegans in the presence and absence of 1-methylnicotinamide (MNA) and nicotinic acid (NA)
Sirtuins, a family of histone deacetylases, have a fiercely debated role in regulating lifespan of different species. Contrasting recent observations, we here find that overexpression of sir-2.1, the orthologue of mammalian SirT1, does extend C. elegans lifespan. Sirtuins are known to convert NAD+ i...
ORGANISM(S): Caenorhabditis elegans 
2013-08-09 | E-GEOD-49662 | biostudies-arrayexpress
MetabolomicsNicotinamide Riboside is Uniquely Bioavailable in People and Mice
Nicotinamide riboside (NR) is in wide use as an NAD+ precursor vitamin. Here we conducted experiments to determine the time and dose-dependent effects of NR on blood, liver and heart NAD+ metabolism in people and mice. We report that human blood cell NAD+ can rise as much as 2.7-fold with a single d...
2016-09-09 | MTBLS368 | MetaboLights
TranscriptomicsTranscription profiling of brains from wild type and beta4 nicotinic acetylcholine receptor (nAChR) subunit deficient mice to identify genes that might be related to beta4-containing nAChRs activity
Studies using mice with beta4 nicotinic acetylcholine receptor (nAChR) subunit deficiency (beta4-/- mice) helped reveal the roles of this subunit in bradycardiac response to vagal stimulation, nicotine-induced seizure activity and anxiety. In order to identify genes that might be related to beta4-co...
ORGANISM(S): Mus musculus 
2007-11-27 | E-GEOD-5320 | biostudies-arrayexpress
TranscriptomicsCandida glabrata transcription profile when grown under Niacin starvation or in human urine
The transcription profile of Candida glabrata grown under two different Niacin limitation conditions were determined. Condition 1 is comparing log phase C. glabrata cells (O.D. 0.5-0.6) grown in synthetic medium containing 0.016 uM versus 3.25 uM nicotinic acid (NA), a common form of Niacin. The NA ...
ORGANISM(S): Candida glabrata 
2010-06-05 | E-GEOD-6582 | biostudies-arrayexpress
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