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ProteomicsProteome solubility changes under different proteostasis stresses
The accumulation of aberrant protein aggregates in neurodegenerative diseases is associated with a widespread failure of the protein homeostasis system. To investigate whether there is a subproteome that consistently aggregates under stress and define the broader determinants for protein aggregation...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-29 | PXD014420 | Pride
Proteome solubility Proteomics Stress response Proteostasis 
ProteomicsProteome solubility changes under different proteostasis stresses
The accumulation of aberrant protein aggregates in neurodegenerative diseases is associated with a widespread failure of the protein homeostasis system. To investigate whether there is a subproteome that consistently aggregates under stress and define the broader determinants for protein aggregation...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-29 | PXD015573 | Pride
Metabolism Huntington’s disease Protein homeostasis Protein aggregation Er-mediated folding inhibition Stress granule formation Aggregomics Nuclear pore Hsp70 Protein misfolding Molecular chaperones Oxidative stress Hsp90 Proteasome 
ProteomicsNovel phenotypes of immune-mediated necrotizing myopathy identified independent of myositis-specific antibody specificity that improve prognostic stratification
Immune-mediated necrotizing myopathy (IMNM) is a severe autoimmune myopathy with high clinical heterogeneity. Current classification relies on myositis-specific antibodies (MSA: anti-HMGCR, anti-SRP) but fails to explain differences in manifestations, interstitial lung disease (ILD) incidence, and s...
ORGANISM(S): Homo Sapiens 
2026-05-06 | PXD078154 |
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