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ProteomicsProteomic profiling identifies muscle-invasive bladder cancers with distinct biology and responses to platinum-based chemotherapy
Platinum-based neoadjuvant chemotherapy (NAC) prior to radical cystectomy is the preferred treatment for muscle-invasive bladder cancer (MIBC) despite modest survival benefit and significant associated toxicities. Here, we profiled the global proteome of MIBC tumours pre- and post-NAC treatment usin...
ORGANISM(S): Homo sapiens (Human) 
2025-02-11 | PXD049435 | Pride
Bladder cancer Mibc 
TranscriptomicsTranscription profiling of yeast grown in a three-factor design to study the relationship between specific growth rate and genome-wide gene expression
A three-factor design was applied to study the relationship between specific growth rate and genome-wide gene expression in 36 steady-state chemostat cultures of Saccharomyces cerevisiae.
ORGANISM(S): Saccharomyces cerevisiae 
2009-01-15 | E-MTAB-78 | biostudies-arrayexpress
ProteomicsEndogenous, in vivo, and site-specific characterization of the SUMO architecture across species and organs
Small ubiquitin-like modifiers (SUMOs) are post-translational modifications that play crucial roles in most cellular processes. While methods exist to study exogenous SUMOylation, large-scale characterization of endogenous SUMO has remained technically daunting. Here, we describe a proteomics approa...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2018-06-26 | PXD008003 | Pride
Tissue Sumo In vivo Endogenous Human Mouse Cells 
ProteomicsThe CASP3 Prodomain Regulates Human Cell Survival and Proliferation
CASPASE-3 (CASP3) is well known for its proteolytic function that mediates multiple key cell death-initiated processes and other related cellular processes. However, the possibility that CASP3 may also possess important additional non-catalytic functions in mammalian cells has remained largely unexp...
ORGANISM(S): Homo sapiens (Human) 
2024-01-17 | PXD045234 | Pride
Casp3 Mammary cells 
UnknownDependence of human cell survival and proliferation on the CASP3 prodomain.
Not available
S-EPMC10847432 | biostudies-literature
TranscriptomicsTranscription profiling of S. cerevisiae chemostat cultures limiting for carbon, nitrogen, phosphorus, sulfur under aerobic and anaerobic conditions
The goal of this study was to study this interaction by analyzing genome-wide transcriptional responses to four different nutrient-limitation regimes under aerobic and anaerobic conditions in chemostat cultures of S. cerevisiae. This ‘two-dimensional’ approach resulted in a new, robust set of â€...
ORGANISM(S): Saccharomyces cerevisiae 
2007-07-09 | E-GEOD-1723 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae response to nitrogen limitation in chemostat culture
Zinc is indispensable for the catalytic activity and structural stability of many proteins, and its deficiency can have severe consequences for microbial growth in natural and industrial environments. For example, Zn depletion in wort negatively affects beer fermentation and quality. Several studies...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-15 | E-GEOD-8089 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae to zinc limitation in chemostat cultures
Zinc is indispensable for the catalytic activity and structural stability of many proteins, and its deficiency can have severe consequences for microbial growth in natural and industrial environments. For example, Zn depletion in wort negatively affects beer fermentation and quality. Several studies...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-15 | E-GEOD-8035 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae response to carbon limitation in aerobic chemostat cultures
Zinc is indispensable for the catalytic activity and structural stability of many proteins, and its deficiency can have severe consequences for microbial growth in natural and industrial environments. For example, Zn depletion in wort negatively affects beer fermentation and quality. Several studies...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-15 | E-GEOD-8088 | biostudies-arrayexpress
TranscriptomicsRIP-seq to identify transcripts interacting with pluripotency factors in mouse embryonic stem cells
Sox2 is a master transcriptional regulator of embryonic development. Having found that Sox2 interacts with RNA-binding proteins, we designed an experiment to discover RNAs associated with Sox2 and other pluripotency factors. Briefly, we used RNA immunoprecipitation followed by high-throughput sequen...
ORGANISM(S): Mus musculus 
2019-02-11 | E-MTAB-7640 | biostudies-arrayexpress
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