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ProteomicsThe CASP3 Prodomain Regulates Human Cell Survival and Proliferation
CASPASE-3 (CASP3) is well known for its proteolytic function that mediates multiple key cell death-initiated processes and other related cellular processes. However, the possibility that CASP3 may also possess important additional non-catalytic functions in mammalian cells has remained largely unexp...
ORGANISM(S): Homo sapiens (Human) 
2024-01-17 | PXD045234 | Pride
Casp3 Mammary cells 
GenomicsCASP3-CASP7
Proteolytic activation of CASP3 and -7 non-redundantly regulates different physiological processes
PRJEB111758 | ENA
GenomicsBulkRNA sequencing of small intestinal IEC epithelial cells of Casp3/7ΔIEC mice and Casp3/7FL/FL littermates
BulkRNA sequencing of small intestinal IEC epithelial cells of Casp3/7ΔIEC mice and Casp3/7FL/FL littermates
PRJNA762040 | ENA
GenomicsGenome-wide CRISPR screening on cytotoxic T lymphocytes mediated cell killing independent of Casp3
Genome-wide CRISPR screening on cytotoxic T lymphocytes mediated cell killing independent of Casp3
PRJNA1481456 | ENA
GenomicsGenome-wide CRISPR screening on cytotoxic T lymphocytes mediated cell killing independent of Casp3, Mlkl, and Bid
Genome-wide CRISPR screening on cytotoxic T lymphocytes mediated cell killing independent of Casp3, Mlkl, and Bid
PRJNA1481243 | ENA
TranscriptomicsBulkRNA sequencing of small intestinal IEC epithelial cells of Casp3/7ΔIEC mice and Casp3/7FL/FL littermates
Apoptosis is widely believed to be crucial for epithelial cell death and shedding in the intestine, thereby shaping the overall architecture of the gastrointestinal tract, but also regulating tolerance induction during homeostasis. To experimentally address this concept, we generated intestinal epit...
ORGANISM(S): Mus musculus 
2022-01-01 | GSE183811 | GEO
OtherGenome-wide CRISPR screening on cytotoxic T lymphocytes mediated cell killing independent of Casp3
To gain insight into cytotoxic lymphocyte–mediated, Casp3-independent cancer cell death, we leveraged the a CTL–αCD3–P815 killing system and performed a genome-wide CRISPR screen. Cas9 expressing and Casp3-/- mouse mastocytoma P815 cells were first transduced with Brie gRNA library and subjected to ...
ORGANISM(S): Mus musculus 
2026-06-26 | GSE336303 | GEO
UnknownDependence of human cell survival and proliferation on the CASP3 prodomain.
Not available
S-EPMC10847432 | biostudies-literature
OtherGenome-wide CRISPR screening on cytotoxic T lymphocytes mediated cell killing independent of Casp3, Mlkl, and Bid
To gain insight into cytotoxic lymphocyte–mediated, Casp3, necroptosis, and Mitochondrial outer membrane permeabilization (MOMP) independent cancer cell death, we leveraged the a CTL–αCD3–P815 killing system and performed a genome-wide CRISPR screen. Cas9 expressing and Casp3-/-Mlkl-/-Bid-/- mouse m...
ORGANISM(S): Mus musculus 
2026-06-26 | GSE336305 | GEO
UnknownCommon variants in CASP3 confer susceptibility to Kawasaki disease.
Not available
S-EPMC2893807 | biostudies-literature
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