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ProteomicsAutophagy is dispensable for the maintenance of parvalbumin interneurons but required for their inhibitory neurotransmission and memory
Previous studies have demonstrated the requirement of autophagy for neuronal survival and synaptic function, mostly focusing on projection neurons and excitatory neurotransmission. Here, we examine the effects of conditional atg5 ablation in neurons expressing parvalbumin (PV-cKO), which in the fore...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-02 | PXD035264 | Pride
Autophagy Mus musculus Neurons Fusion 
ProteomicsAutophagic vesicle content profiling from hippocampal slices LC-MSMS
Previous work demonstrated that the developmental pruning of dendritic spines requires autophagy. This developmental process is facilitated by long-term depression (LTD)-like mechanisms, inviting the speculation that LTD, a fundamental form of plasticity, itself requires autophagy. Here, we show tha...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-10 | PXD030079 | Pride
Synaptic plasticity Autophagosome Cargo Long-term depression Autophagy 
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