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ProteomicsThe SUMO-NIP45 pathway guards against accumulation of toxic DNA catenanes
SUMOylation is an essential protein modification that regulates numerous biological processes, but what constitutes its most critical functions in the cell remains unclear. Here, using genome-scale CRISPR-Cas9-based synthetic lethality screens, we show that the BLM-TOP3A-RMI1-RMI2 (BTRR)-PICH pathwa...
ORGANISM(S): Homo sapiens (Human) 
2023-07-21 | PXD033739 | Pride
Btrr Sumo Sumoylation Pich Human Dna catenane Dna damage Slx4 Nip45 
UnknownThe SUMO-NIP45 pathway processes toxic DNA catenanes to prevent mitotic failure.
Not available
S-EPMC10497417 | biostudies-literature
UnknownProteins with two SUMO-like domains in chromatin-associated complexes: the RENi (Rad60-Esc2-NIP45) family.
Not available
S-EPMC549199 | biostudies-literature
ProteomicsCho_NFATC2IP_timsTOFPro2_P124_VS15
This dataset consists of 4 raw MS files and associated peak lists and results files, acquired on a Bruker timsTOF Pro 2 operated in Data Dependent Acquisition mode. Samples were generated by Tiffany Cho. Affinity purification was performed by Tiffany Cho and Laura McGary. Mass spectrometry acquisit...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-03-05 | MSV000094236 | MassIVE
UnknownTargeted deletion of NFAT-Interacting-Protein-(NIP) 45 resolves experimental asthma by inhibiting Innate Lymphoid Cells group 2 (ILC2).
Not available
S-EPMC6821848 | biostudies-literature
UnknownRole of nuclear factor of activated T cells 2 (NFATc2) in allergic asthma.
Not available
S-EPMC7654396 | biostudies-literature
TranscriptomicsMultifaceted down-regulation of the Srs2 helicase by the SUMO-like domain protein Esc2 promotes local recombination at sites of stalled replication
The SUMO-like domains-containing family of proteins to which Saccharomyces cerevisiae Esc2 belongs facilitates DNA damage tolerance (DDT) via elusive mechanisms. Here we report that Esc2 promotes recombination-mediated DDT by engaging in functional and physical interactions with Srs2 and Elg1, two r...
ORGANISM(S): Saccharomyces cerevisiae 
2015-02-16 | E-GEOD-65701 | biostudies-arrayexpress
TranscriptomicsSABiosciences Human miRNA PCR array assay of normal respiratory epithelia and lung cancer cells with or without treatment of CSC
MicroRNAs are critical mediators of stem cell pluripotency, differentiation and malignancy. Limited information exists regarding microRNA alterations that facilitate initiation and progression of human lung cancers. In this study, array techniques were used to evaluate microRNA expression in norma...
ORGANISM(S): Homo sapiens 
2012-12-18 | E-GEOD-42962 | biostudies-arrayexpress
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