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UnknownExploration of Catalytic Selectivity for Aminotransferase (BtrR) Based on Multiple Molecular Dynamics Simulations.
Not available
S-EPMC6429434 | biostudies-literature
TranscriptomicsTranscriptomic analysis to identify the putative genes under the regulation of two component system BtrK/BtrR in C. acetobutylicum
To identify the putative genes under the regulation of two component system BtrK/BtrR, we performed a comparative transcriptomic analysis of the BtrK/BtrR overexpressing strain and the contron strain. Finally, we found that BtrK/BtrR was a global regulator and exerted pleiotropic regulatory role in ...
ORGANISM(S): Clostridium acetobutylicum 
2019-10-08 | GSE138466 | GEO
GenomicsTranscriptomic analysis to identify the putative genes under the regulation of two component system BtrK/BtrR in C. acetobutylicum
Transcriptomic analysis to identify the putative genes under the regulation of two component system BtrK/BtrR in C. acetobutylicum
PRJNA576001 | ENA
ProteomicsThe SUMO-NIP45 pathway guards against accumulation of toxic DNA catenanes
SUMOylation is an essential protein modification that regulates numerous biological processes, but what constitutes its most critical functions in the cell remains unclear. Here, using genome-scale CRISPR-Cas9-based synthetic lethality screens, we show that the BLM-TOP3A-RMI1-RMI2 (BTRR)-PICH pathwa...
ORGANISM(S): Homo sapiens (Human) 
2023-07-21 | PXD033739 | Pride
Btrr Sumo Sumoylation Pich Human Dna catenane Dna damage Slx4 Nip45 
ProteomicsCentromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex
The BTRR (BLM/TOP3A/RMI1/RMI2) complex resolves various DNA replication and recombination intermediates to suppress genome instability. Alongside PICH, they target mitotic DNA intertwinements, known as ultrafine DNA bridges, facilitating chromosome segregation. Both BLM and PICH undergo transient mi...
ORGANISM(S): Homo sapiens (Human) 
2025-08-12 | PXD064192 | Pride
Chromosome biorientation Bloom syndrome helicase Cdk1 Mps1 Pich Plk1 Ultrafine dna bridge (ufb)-binding complex Pp1s Rif1 Anaphase dna bridges Centromeres Btrr dissolvasome 
ProteomicsCentromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex
The BTRR (BLM/TOP3A/RMI1/RMI2) complex resolves various DNA replication and recombination intermediates to suppress genome instability. Alongside PICH, they target mitotic DNA intertwinements, known as ultrafine DNA bridges, facilitating chromosome segregation. Both BLM and PICH undergo transient mi...
ORGANISM(S): Homo sapiens (Human) 
2025-08-12 | PXD052669 | Pride
Chromosome biorientation Bloom syndrome helicase Cdk1 Mps1 Pich Plk1 Ultrafine dna bridge (ufb)-binding complex Pp1s Rif1 Anaphase dna bridges Centromeres Btrr dissolvasome 
ProteomicsCentromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex
The BTRR (BLM/TOP3A/RMI1/RMI2) complex resolves various DNA replication and recombination intermediates to suppress genome instability. Alongside PICH, they target mitotic DNA intertwinements, known as ultrafine DNA bridges, facilitating chromosome segregation. Both BLM and PICH undergo transient mi...
ORGANISM(S): Homo sapiens (Human) 
2025-08-27 | PXD052850 | Pride
Chromosome biorientation Bloom syndrome helicase Cdk1 Mps1 Pich Plk1 Ultrafine dna bridge (ufb)-binding complex Pp1s Rif1 Anaphase dna bridges Centromeres Btrr dissolvasome 
ProteomicsMechanistic basis for the spatiotemporal assembly of the Bloom Syndrome complex on ultrafine DNA bridges
The BTRR (BLM/TOP3A/RMI1/RMI2) complex resolves DNA replication and recombination intermediates, as well as mitotic DNA intertwinements, yet how its diverse activities are regulated remains unclear. Here, we identify key determinants of stable assembly of the BTRR complex on ultrafine DNA bridges (U...
ORGANISM(S): Homo sapiens (Human) 
2026-07-30 | PXD081930 | Pride
Bloom syndrome complex Ultrafine dna bridges 
UnknownThe SMC5/SMC6 complex is critical for resolving R-loop-induced transcription-replication conflicts.
Not available
S-EPMC12802942 | biostudies-literature
UnknownThe BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchanges.
Not available
S-EPMC11894219 | biostudies-literature
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