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MetabolomicsBlocking NKp46-CCR6-ILC3 autophagy alleviates necrotizing enterocolitis by restoring energy metabolism balance

Group 3 innate lymphoid cells (ILC3s) play a crucial role in intestinal inflammatory disorders such as necrotizing enterocolitis (NEC) in neonates; however, the mechanisms by which ILC3s contribute to NEC remain unclear. In this study, single-cell transcriptomics, in vivo experiments on T cell-de...

2026-04-12 | MTBLS12891 | MetaboLights
ProteomicsHDX-MS analysis of NKp46 with next gen antibodies
Eptiopes of 7 unique antibodies produced by two complementary in vivo platforms utilizing a common light chain, in a chicken (OmniClic) or rat (OmniFlic) host species on NKp46 were analysed using HDX-MS. NKp46 was used as a model target antigen due to its use in emerging Natural Killer (NK) immune e...
ORGANISM(S): Homo sapiens (Human) 
2025-11-27 | PXD069455 | Pride
Epitope Antibody Nkp46 Hdx 
TranscriptomicsGene expression profiling of small intestine (SI) NKp46+RORgt+ and NKp46+RORgt- Innate Lymphoid Cells (ILCs)
The aim of this study was to analyze the global transcriptional profiles of small intestine (SI) Innate Lymphoid Cells (ILCs) expressing the NK cell marker NKp46. Based on differential expression of the RORgt transcription factor SI NKp46+ ILCs can be divided in NKp46+RORgt- and NKp46+RORgt+ cells. ...
ORGANISM(S): Mus musculus 
2011-06-20 | E-GEOD-29777 | biostudies-arrayexpress
TranscriptomicsMapping and genome-wide profiling of human NKp46+ cells
Understanding Natural Killer (NK) cell anatomical distribution is key to dissect the role of these unconventional lymphocytes in physiological and disease conditions. In mouse, NK cells have been detected in various lymphoid and non-lymphoid organs, while in humans the current knowledge of NK cell d...
ORGANISM(S): Homo sapiens 
2012-11-12 | E-GEOD-41469 | biostudies-arrayexpress
TranscriptomicsGene expression profile at single cell level of vessel associated kidney NKp46+ ILC from healthy and nephritic NZB/W lupus prone mice
Kidney vessel associated NKp46+ ILC have never been characterized at single cell level before. We used single cell RNA sequencing (scRNA-seq) to analyze the diversity of kidney vessel associated NKp46+ ILC in the kidney
ORGANISM(S): Mus musculus 
2026-03-04 | E-MTAB-16156 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of small intestine (SI) NKp46+RORgt+ and NKp46+RORgt- Innate Lymphoid Cells (ILCs)
The aim of this study was to analyze the global transcriptional profiles of small intestine (SI) Innate Lymphoid Cells (ILCs) expressing the NK cell marker NKp46. Based on differential expression of the RORgt transcription factor SI NKp46+ ILCs can be divided in NKp46+RORgt- and NKp46+RORgt+ cells. ...
ORGANISM(S): Mus musculus 
2011-06-20 | GSE29777 | GEO
UnknownIdentity, regulation and in vivo function of gut NKp46+RORγt+ and NKp46+RORγt- lymphoid cells.
Not available
S-EPMC3160256 | biostudies-literature
GenomicsGene expression profile at single cell level of tissue- associated kidney NKp46+NK1.1+ or NK1.1+ ILC from healthy, nephritic and NKp46 blocking antibody treated NZB/W lupus prone mice
Gene expression profile at single cell level of tissue- associated kidney NKp46+NK1.1+ or NK1.1+ ILC from healthy, nephritic and NKp46 blocking antibody treated NZB/W lupus prone mice
PRJNA853793 | ENA
GenomicsNKp46 regulates type 1 innate lymphoid cell proliferation and function and anti-acute myeloid leukemia activity
NKp46 regulates type 1 innate lymphoid cell proliferation and function and anti-acute myeloid leukemia activity
PRJNA1192315 | ENA
TranscriptomicsDifferential roles of ROR gamma-t in the development of NKp46+ spleen (LTIL) cells and NKp46+ NK cells in gut and skin
Natural killer (NK) cells are NKp46+CD3- lymphocytes that can perform granule-dependent cytotoxicity and produce interferon-gamma, when isolated from blood, lymphoid organs, lung, liver and uterus. Here we identify in dermis, gut lamina propria and cryptopatches, very distinct populations of NKp46+C...
ORGANISM(S): Mus musculus 
2008-10-22 | GSE13151 | GEO
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