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ProteomicsNleB host targets - The bacterial arginine glycosyltransferase effector NleB preferentially modifies Fas-associated death domain protein (FADD)
The inhibition of host innate immunity pathways is essential for the survival of attaching and effacing (A/E) pathogens such as enteropathogenic Escherichia coli (EPEC) and Citrobacter rodentium during mammalian infections. To subvert these pathways, A/E pathogens utilize a type III secretion system...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) Escherichia coli 
2017-09-11 | PXD006810 | Pride
Epec Nleb 
UnknownArg-GlcNAcylation on TRADD by NleB and SseK1 Is Crucial for Bacterial Pathogenesis.
Not available
S-EPMC7379376 | biostudies-literature
UnknownEssential role of the type III secretion system effector NleB in colonization of mice by Citrobacter rodentium.
Not available
S-EPMC1418941 | biostudies-literature
UnknownNleB/SseK-catalyzed arginine-glycosylation and enteropathogen virulence are finely tuned by a single variable position contiguous to the catalytic machinery.
Not available
S-EPMC8457375 | biostudies-literature
UnknownThe bacterial arginine glycosyltransferase effector NleB preferentially modifies Fas-associated death domain protein (FADD).
Not available
S-EPMC5655511 | biostudies-literature
UnknownSalmonella phage ST64B encodes a member of the SseK/NleB effector family.
Not available
S-EPMC3060822 | biostudies-literature
ProteomicsArg-GlcNAcylation of GshB, An intra-bacterial activity for a T3SS effector
Many Gram-negative bacterial pathogens interact with mammalian cells by using type III secretion systems (T3SS) to inject virulence proteins directly into infected host cells. A subset of these injected protein ‘effectors’ are enzymes that modify the structure and inhibit the function of human prote...
ORGANISM(S): Escherichia coli 
2020-01-14 | PXD015752 | Pride
Citrobacter rodentium Ehec Nleb Glycosylation Epec Effectors 
ProteomicsThe E. coli type III secreted effectors NleB and EspL interact with the microtubule associated protein ensconsin to disrupt vesicle trafficking, part 1
Enteropathogenic and enterohaemorrhagic E. coli (EPEC and EHEC) translocate a set of type III effector proteins into host cells that are critical for bacterial virulence. These effectors subvert normal host pathways by interacting with a variety of targets within the cell, but the binding partners ...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2016-12-22 | PXD002933 | Pride
Human E. coli Effector Host-pathogen 
UnknownAuto Arginine-GlcNAcylation Is Crucial for Bacterial Pathogens in Regulating Host Cell Death.
Not available
S-EPMC7214673 | biostudies-literature
UnknownA pathogen-derived effector modulates host glucose metabolism by arginine GlcNAcylation of HIF-1α protein.
Not available
S-EPMC6117090 | biostudies-literature
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