Sort   by:  
 Page size 
UnknownDrugs Based on NMDAR Hypofunction Hypothesis in Schizophrenia.
Not available
S-EPMC8072017 | biostudies-literature
ProteomicsEffects of NMDAR on mouse hippocampal neuron (HT22) proteome expression during hypoxia/reoxygenation injury
Brain tissue is extremely sensitive to hypoxia/reoxygenation (H/R) injury, which can easily cause irreversible damage to neurons. H/R injury could induce neuronal apoptosis through glutamate-mediated excitotoxicity. N-methyl-d-aspartate receptor (NMDAR) is one of the main receptors of excitatory glu...
ORGANISM(S): Mus Musculus 
2022-08-24 | PXD036251 |
UnknownTop-Down Suppression of Sensory Cortex in an NMDAR Hypofunction Model of Psychosis.
Not available
S-EPMC6811829 | biostudies-literature
UnknownGABAB-mediated rescue of altered excitatory-inhibitory balance, gamma synchrony and behavioral deficits following constitutive NMDAR-hypofunction.
Not available
S-EPMC3410621 | biostudies-literature
ProteomicsNMDA glutamate receptor antagonist MK-801 induces proteome changes in adult human brain slices which are partially counteracted by haloperidol and clozapine
Deciphering the molecular pathways associated with N-methyl-D-aspartate receptor (NMDAr) hypofunction and its interaction with antipsychotics is necessary to advance our understanding of the basis of schizophrenia, as well as our capacity to treat this disease. In this regard, the development of hum...
ORGANISM(S): Homo sapiens (Human) 
2024-02-06 | PXD046944 | Pride
Nmdar hypofunction Haloperidol Schizophrenia Antipsychotics Organotypic culture Clozapine 
TranscriptomicsEffects of NMDAR on mouse hippocampal neuron (HT22) mRNA and lncRNA expression during hypoxia/reoxygenation injury
To investigate the changes of the transcriptome in neuronal cells under the condition of NMDAR hypofunction and H/R injury, we compared the changes of mRNA and lncRNA expression levels in mouse hippocampal neuron HT22 cell with or without NMDAR knockdown and H/R stimulation by RNA sequencing.
ORGANISM(S): Mus musculus 
2022-10-10 | GSE214716 | GEO
UnknownNeural substrates of cognitive impairment in a NMDAR hypofunction mouse model of schizophrenia and partial rescue by risperidone.
Not available
S-EPMC10104169 | biostudies-literature
UnknownSubunit-specific NMDAR antagonism dissociates schizophrenia subtype-relevant oscillopathies associated with frontal hypofunction and hippocampal hyperfunction.
Not available
S-EPMC6072790 | biostudies-literature
GenomicsEffects of NMDAR on mouse hippocampal neuron (HT22) mRNA and lncRNA expression during hypoxia/reoxygenation injury
Effects of NMDAR on mouse hippocampal neuron (HT22) mRNA and lncRNA expression during hypoxia/reoxygenation injury
PRJNA886848 | ENA
ProteomicsHuman NMDAR autoantibodies disrupt excitatory-inhibitory balance leading to hippocampal network hypersynchrony
Specific autoantibodies against the NMDA-receptor (NMDAR) GluN1 subunit cause severe and debilitating NMDAR-encephalitis. Autoantibodies induce prototypic disease symptoms resembling schizophrenia, including psychosis and cognitive dysfunction. Using a mouse passive transfer model applying human mon...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-24 | PXD032055 | Pride
Network oscillation Excitatory-inhibitory imbalance Autoantibodies Nmda receptor encephalitis Nmda receptor Theta-gamma coupling Neural network modeling 
Sort   by:  
 Page size