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ProteomicsKinase-catalyzed Biotinylation for Discovery and Validation of Substrates to Multi-specificity Kinases NME1 and NME2
Protein phosphorylation by kinases regulates mammalian cell functions, such as growth, division, and signal transduction. Among human kinases, NME1 and NME2 are associated with metastatic tumor suppression, but remain understudied due to the lack of tools to monitor their cellular substrates. In par...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD051411 | Pride
Proteomics Histidine kinase Phosphorylation Nme Substrate specificity Atp-biotin Protein kinase 
GenomicsExtracellular Vesicle-Mediated Metastasis Suppressors NME1 and NME2 Modify Lipid Metabolism in Fibroblasts
Extracellular Vesicle-Mediated Metastasis Suppressors NME1 and NME2 Modify Lipid Metabolism in Fibroblasts
PRJNA870897 | ENA
ProteomicsMS-based analysis of enzymatic methylation of an in vitro-transcribed lncRNA
The field of epitranscriptomics is growing in importance, with chemical modification of RNA being associated with a wide variety of biological phenomena. Mass spectrometry (MS) enables the identification of modified RNA residues within their sequence contexts, by using analogous approaches to shotgu...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-03-31 | PXD016308 | Pride
5-methylcytidine Rna Epitranscriptomics Lncrna M5c Nme1 
ProteomicsMS-based analysis of enzymatic methylation of an in vitro-transcribed lncRNA
The field of epitranscriptomics is growing in importance, with chemical modification of RNA being associated with a wide variety of biological phenomena. Mass spectrometry (MS) enables the identification of modified RNA residues within their sequence contexts, by using analogous approaches to shotgu...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2018-12-31 | PXD012095 | Pride
5-methylcytidine Rna Epitranscriptomics Lncrna M5c Nme1 
TranscriptomicsIdentification of a gene expression signature associated with the metastasis suppressor function of NME1
Transciptome analysis using a panel of WM793 melanoma cell lines following stable overexpression of wild-type or mutant forms of human NME1 NME1 is well known for its ability to suppress melanoma metastasis, however the means by which NME1 accomplishes this remains controversial. Herein, we utilized...
ORGANISM(S): Homo sapiens 
2017-08-22 | GSE85978 | GEO
TranscriptomicsExtracellular Vesicle-Mediated Metastasis Suppressors NME1 and NME2 Modify Lipid Metabolism in Fibroblasts
Our aim was to understand how vesicular NME1 and NME2 released by breast cancer cells influence the tumour microenvironment. As a model, we used human invasive breast carcinoma cells overexpressing NME1 or NME2, and first analysed in detail the presence of both isoforms in EV subtypes by capillaryWe...
ORGANISM(S): Homo sapiens 
2022-08-21 | GSE211556 | GEO
ProteomicsNucleoside diphosphate kinase A (NME1) catalyzes its own oligophosphorylation
Protein phosphorylation is a central regulatory mechanism in eukaryotic cell signaling, and was recently expanded to include protein pyrophosphorylation and protein polyphosphorylation. Here, we report the discovery of yet another mode of phosphorylation – protein oligophosphorylation. Using site-sp...
ORGANISM(S): Homo sapiens (Human) 
2025-08-21 | PXD054175 | Pride
Oligophosphorylation Open-search Phosphorylation 
UnknownThe Potential Functional Roles of NME1 Histidine Kinase Activity in Neuroblastoma Pathogenesis.
Not available
S-EPMC7247550 | biostudies-literature
UnknownRegulation of metastasis suppressor NME1 by a key metabolic cofactor coenzyme A.
Not available
S-EPMC8212152 | biostudies-literature
UnknownHeat-shock protein 90α protects NME1 against degradation and suppresses metastasis of breast cancer.
Not available
S-EPMC10645775 | biostudies-literature
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