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ProteomicsRibonucleotide synthesis by NME6 fuels mitochondrial gene expression
Replication and expression of the mitochondrial genome depend on the sufficient supply ofnucleotide building blocks to mitochondria. Dysregulated nucleotide metabolism is detrimental tomitochondrial genomes and can destabilise mitochondrial DNA and trigger inflammation. Here, wereport that a mitocho...
ORGANISM(S): Homo sapiens (Human) 
2023-05-04 | PXD038391 | Pride
Mitochondria Ribonucleotide Nme6 Rntps Lc-ms/ms 
ProteomicsRegulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression
Mitochondrial oxidative phosphorylation (OXPHOS) complexes are assembled from proteins encoded by both nuclear and mitochondrial DNA. These dual-origin enzymes pose a complex gene regulatory challenge for cells requiring coordinated gene expression across organelles. To identify genes involved in du...
ORGANISM(S): Homo sapiens (Human) 
2023-08-23 | PXD044812 | Pride
Ip-massspec K562 Prepl Nme6 
UnknownRibonucleotide synthesis by NME6 fuels mitochondrial gene expression.
Not available
S-EPMC10505918 | biostudies-literature
UnknownMitochondrial NME6 Influences Basic Cellular Processes in Tumor Cells In Vitro.
Not available
S-EPMC11395177 | biostudies-literature
UnknownNME6 is a phosphotransfer-inactive, monomeric NME/NDPK family member and functions in complexes at the interface of mitochondrial inner membrane and matrix.
Not available
S-EPMC8597243 | biostudies-literature
UnknownRibonucleotide synthesis by NME6 fuels mitochondrial gene expression
Not available
S-SCDT-10_15252-EMBJ_2022113256 | biostudies-other
TranscriptomicsRegulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression
Mitochondrial oxidative phosphorylation (OXPHOS) complexes are assembled from proteins encoded by both nuclear and mitochondrial DNA. These dual-origin enzymes pose a complex gene regulatory challenge for cells requiring coordinated gene expression across organelles. To identify genes involved in du...
ORGANISM(S): Homo sapiens 
2023-08-17 | GSE240576 | GEO
OtherRegulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression
Mitochondrial oxidative phosphorylation (OXPHOS) complexes are assembled from proteins encoded by both nuclear and mitochondrial DNA. These dual-origin enzymes pose a complex gene regulatory challenge for cells requiring coordinated gene expression across organelles. To identify genes involved in du...
ORGANISM(S): Homo sapiens 
2023-08-17 | GSE224817 | GEO
OtherRegulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression
Mitochondrial oxidative phosphorylation (OXPHOS) complexes are assembled from proteins encoded by both nuclear and mitochondrial DNA. These dual-origin enzymes pose a complex gene regulatory challenge for cells requiring coordinated gene expression across organelles. To identify genes involved in du...
ORGANISM(S): Homo sapiens 
2023-08-17 | GSE224503 | GEO
OtherRegulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression
Mitochondrial oxidative phosphorylation (OXPHOS) complexes are assembled from proteins encoded by both nuclear and mitochondrial DNA. These dual-origin enzymes pose a complex gene regulatory challenge for cells requiring coordinated gene expression across organelles. To identify genes involved in du...
ORGANISM(S): Homo sapiens 
2023-08-17 | GSE224818 | GEO
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