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ProteomicsDOPA formation on tyrosine Y150 of Ribonucleotide reductase QSK R2e variant from Gardnerella vaginalis.
With a crystal structure and mass spectrometry on recombinantly expressed and purified Ribonucleotide reductase QSK R2e variant from Gardnerella vaginalis we show that this protein has a modified DOPA (3,4-Dihydroxy-L-phenylalanine) in the active site analogous to what was observed for the VPK varia...
ORGANISM(S): Gardnerella vaginalis 
2023-09-08 | PXD045227 | Pride
Qexactive hf 3 Ptm Gardnerella vaginalis 4-dihydroxyphenylalanine Tyrosine Ribonuclotide reductase Dopa 
ProteomicsRibonucleotide synthesis by NME6 fuels mitochondrial gene expression
Replication and expression of the mitochondrial genome depend on the sufficient supply ofnucleotide building blocks to mitochondria. Dysregulated nucleotide metabolism is detrimental tomitochondrial genomes and can destabilise mitochondrial DNA and trigger inflammation. Here, wereport that a mitocho...
ORGANISM(S): Homo sapiens (Human) 
2023-05-04 | PXD038391 | Pride
Mitochondria Ribonucleotide Nme6 Rntps Lc-ms/ms 
GenomicsRibonucleotide incorporation into mitochondrial DNA induces cGAS-STING dependent inflammation
Ribonucleotide incorporation into mtDNA
PRJEB87869 | ENA
TranscriptomicsEffect of 5-amino-4-imidazolecarboxamide ribotide (AICAr) supplementation on global transcription
We investigated the effects of AICAr supplementation on the global transcriptome of Y2950. The Y2950 strain was grown with or without AICAr. For each comparison, we made 2 biological replicates, swapping dyes.
ORGANISM(S): Saccharomyces cerevisiae 
2011-08-31 | E-GEOD-29019 | biostudies-arrayexpress
TranscriptomicsRole of Ado1p in the transcriptional response associated with AICAr supplementation
We investigated the role of Ado1p associated with AICAr supplementation on the global transcriptome of Y3188. The Y3188 strain was grown with or without AICAr. For each comparison, we made 2 biological replicates, swapping dyes.
ORGANISM(S): Saccharomyces cerevisiae 
2011-08-31 | E-GEOD-29020 | biostudies-arrayexpress
GenomicsRibonucleotide excision repair prevents intestinal tumorigenesis
Ribonucleotide excision repair prevents intestinal tumorigenesis
PRJNA436583 | ENA
TranscriptomicsEffect of AICAr and SAICAr accumulation on global transcription in the ade3 mutant
We investigated the effects of AICAr and SAICAr accumulation on the global transcriptome of yeast, comparing the ade3 mutant to the WT strain. The ade3 mutant strain (Y4143) was compared to the WT strain (Y2946). For each comparison, we made 2 technical replicates, swapping dyes.
ORGANISM(S): Saccharomyces cerevisiae 
2011-08-31 | E-GEOD-29021 | biostudies-arrayexpress
GenomicsMapping polymerase usage by tracking ribonucleotide incorporation (HydEn-seq) during DNA replication
Mapping polymerase usage by tracking ribonucleotide incorporation (HydEn-seq) during DNA replication
PRJNA517710 | ENA
TranscriptomicsThe Anticancer Mechanism of the Ribonucleotide Reductase Inhibiting Drug COH29 Involves Suppression of DNA Repair
Mechanism of Action Study for COH29 Compare COH29 treatment in DNA-repair deficient cell line with truncated BRCA1 (HCC1937) versus phenotypically normal cell line with exogenous WT BRCA1 expression (HCC1937+BRCA1)
ORGANISM(S): Homo sapiens 
2015-05-08 | E-GEOD-55004 | biostudies-arrayexpress
GenomicsRibonucleotide excision repair is essential to prevent skin cancer [CD49f+ epidermal cells]
Ribonucleotide excision repair is essential to prevent skin cancer [CD49f+ epidermal cells]
PRJNA473507 | ENA
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