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MetabolomicsThe GNMT N-terminus Couples Folate Feedback to Methyl-donor Homeostasis
Maintenance of S-adenosylmethionine (SAM) homeostasis is essential for methylation of biomolecules, nucleotide and polyamine synthesis, and redox balance. While all methyltransferases consume SAM, only a subset of highly tissue specific methyltransferases regulates methylation potential. Among them,...
2026-08-18 | MTBLS15161 | MetaboLights
MetabolomicsFaecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients

BACKGROUND: The gut-brain axis and the intestinal microbiota are emerging as key players in health and disease. Shifts in intestinal microbiota composition affect a variety of systems, however, evidence of their direct impact on cognitive functions is still lacking. We tested whe...

2021-12-17 | MTBLS1437 | MetaboLights
MetabolomicsPrimary T Cell Noxa Knockdown (Donor 8) III
Not available
ORGANISM(S): Homo sapiens 
ST000370 | MetabolomicsWorkbench
MetabolomicsPrimary T Cell Noxa Knockdown (Donor 8)-II
Not available
ORGANISM(S): Homo sapiens 
ST000153 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of human soluble guanylate cyclase-deficient U937 cells exposed to the nitric oxide (NO) donor S-nitrosoglutathione to provide insight into the cGMP-independent effects of NO
NO effects on gene expression, independent of cGMP, were examined globally. Differentiated human U937 cells that lack soluble guanylate cyclase were exposed to Snitrosoglutathione, a NO donor, or glutathione without or with dibutyryl-cAMP (Bt2cAMP). NO regulated 110 transcripts that annotated dispro...
ORGANISM(S): Homo sapiens 
2007-09-11 | E-GEOD-2649 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human adult to adult living donor liver grafts compared to deceased donor grafts
Because of inherent differences between deceased donor (DD) and living donor (LD) liver grafts, we hypothesize that the molecular signatures will be unique, correlating with specific biologic pathways and clinical patterns. Following reperfusion, 579 genes in DD grafts and 1324 genes in LDs were ...
ORGANISM(S): Homo sapiens 
2009-06-23 | E-GEOD-12720 | biostudies-arrayexpress
TranscriptomicsDonor lung tissues: Control vs. Primary graft dysfunction (PGD)
Primary graft dysfunction (PGD) continues to be a major cause of early death after lung transplantation. Moreover, there remains a lack of accurate pre-transplant molecular markers for predicting PGD. To identify distinctive gene expression signatures associated with PGD, we profiled human donor lun...
ORGANISM(S): Homo sapiens 
2008-09-15 | E-GEOD-9102 | biostudies-arrayexpress
GenomicsThe transcriptome assembly of the Pm13 donor line No. 3778
The transcriptome assembly of the Pm13 donor line No. 3778
PRJEB77657 | ENA
TranscriptomicsCadaveric vs. live donor kidneys
Recipients of live donor transplant kidneys (LIV) exhibit a significantly longer allograft half-life compared with cadaveric donor organs (CADs). The reasons are incompletely understood. Therefore this study sought to elucidate the genome-wide gene expression profiles in microdissected transplant ki...
ORGANISM(S): Homo sapiens 
2006-01-11 | E-GEOD-4018 | biostudies-arrayexpress
ProteomicsComparison of Transcript and Protein Abundance in Human Donor Retinas Support Extending Post-Mortem Interval from 12- to 18-hours to Expand the Donor Pool for Biomedical Research
Extending the post-mortem interval (PMI) from 12- to 18-hours was done to see if transcript and protein abundance in the human retina changed. Donor eyes were recovered from post-mortem donors (n=7 pairs) and stored at 2–8°C. Only donor eyes with ocular cooling within 8 hours of death were examined....
ORGANISM(S): Homo sapiens (Human) 
2026-04-07 | PXD068030 | Pride
Tmtpro Mass spectrometry Retina Orbitrap tribrid sps-ms3 acquisition Donor collection time Isobaric labeling quantitative proteomics 
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