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TranscriptomicsGene expression profiles of CD4+CD25+ Tregs from NOD and B6.H2g7 mice
The NOD (nonobese diabetic) mouse strain develops a characteristic autoimmune syndrome that closely resembles human type I diabetes. It has been suggested that NOD mice exhibit both numerical deficiency in CD4+CD25+ regulatory T cells (Treg) and reduced suppressive activity. We compared sorted CD4...
ORGANISM(S): Mus musculus 
2008-12-19 | E-GEOD-6813 | biostudies-arrayexpress
TranscriptomicsGene expression in the pancreatic lymph nodes (PLN) of hyperglycemic 16-week-old Non-Obese Diabetic (NOD) mice compared to expression the PLN of euglycemic 16-week-old NOD mice.
These experiments were performed to identify differentially expressed genes in the pancreatic lymph nodes of hyperglycemic NOD mice with high levels of destructive insulitis compared to euglycemic mice with lower levels of insulitis. The pancreatic lymph nodes of 16-week-old hyperglycemic and euglyc...
ORGANISM(S): Mus musculus 
2014-06-01 | E-GEOD-57237 | biostudies-arrayexpress
TranscriptomicsGene expression in the isolated islets of 10 day old, 4 wk old, 12 wk old, and 20 wk old Non-Obese Diabetic (NOD) mice compared to healthy age matched control NOD.B10 mice
Gene expression in the islets of diseased NOD mice compared to congenic healthy NOD.B10 mice at various ages, during the progression of NOD disease. Islets were isolated from individual NOD and NOD.B10 mice by collagenase digestion. RNA was extracted using Trizol, combined with the RNeasy micro kit ...
ORGANISM(S): Mus musculus 
2013-11-28 | E-GEOD-52815 | biostudies-arrayexpress
OtherType 1 Diabetes Prone NOD Mice Have Diminished Cxcr1 mRNA Expression in Polymorphonuclear Neutrophils and CD4+ T Lymphocytes.
Data from ProteomeXchange, PXD ID: PXD003015. File: OB07268.mzml. Published as part of PLoS One. 2015 Jul 31;10(7):e0134365 . From the Abstract: {{i}} ... Here, we report descriptive data about the Cxcr1 gene in NOD mice ... {{/i}}
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32310024995 | GPMDB
Resource Reanalysis 
TranscriptomicsThe NOD/SCID Xenograft Model Provides Clinically-Relevant Insights into Glucocorticoid-Induced Gene Expression in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia
Introduction. Glucocorticoids are critical drugs used to treat acute lymphoblastic leukemia, and response to glucocorticoids is highly predictive of outcome. Here we report a study evaluating the NOD/SCID xenograft mouse model to investigate glucocorticoid-induced gene expression. Methods. NOD/SCID ...
ORGANISM(S): Homo sapiens 
2011-11-28 | E-GEOD-30392 | biostudies-arrayexpress
ProteomicsPancreatic beta cell proteome with increased proliferation in NOD mice
We investigated the pancreatic beta cell proteome changes in NOD-LIRKO vesus NOD where beta cell mass was enhanced early in life. Proteomics data is derived from FACS-sorted beta cells at 8 weeks and 12 weeks.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-03-14 | MSV000083576 | MassIVE
TranscriptomicsGenomic profiling of type-1 adult diabetic and aged normoglycemic mice liver
Here we characterized and compared differential gene expression from diabetic and normoglycemic NOD mice and from aged and young-adults Balb/c mice. Total RNA from NOD diabetic (3 weeks with glicemia over 500mg/dl) and normoglycemic NOD mice from the same age was used. To compare the effects of agin...
ORGANISM(S): Mus musculus 
2013-09-06 | E-GEOD-50613 | biostudies-arrayexpress
TranscriptomicsIFN-alpha induced gene expression profile in NOD/BDC2.5 and NOD mice.
With the goal of identifying changes in gene expression in CD4(+) T cells during the development of diabetes in the nonobese diabetic (NOD) mouse, we used DNA microarrays to analyze gene expression in CD4(+) T cells from the pancreatic draining lymph nodes of NOD/BDC 2.5 T cell receptor transgenic a...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-15213 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of NOD mice and related congenic mice
Functional liability conferred by gene expression profile can be a possible basis for diseases phenotype. By comparing gene expression profiles in splenic T cells from NOD, C57BL/6 mice and their congenic strains with altered MHCs (NOD.H2^h4 , B6.NOD/Idd1,5/), we identified that the NOD splenic T ce...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-2524 | biostudies-arrayexpress
TranscriptomicsOver expression of mRNA for multiple genes including insulin in the PLN of NOD is associated with Islet Autoimmunity
The aim of this study is to identify genes implicated in the early steps of the autoimmune process, prior to inflammation in type 1 diabetes. Early Insulin AutoAntibodies (E-IAA) have been used as subphenotypic marker to select individual animals as type 1 diabetes prone and to compare gene expressi...
ORGANISM(S): Mus musculus 
2009-10-02 | E-GEOD-15582 | biostudies-arrayexpress
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