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TranscriptomicsMetastable pluripotent states in NOD mouse derived ES cells
Embryonic stem (ES) cells are isolated from the inner cell mass (ICM) of developing blastocysts, whereas epiblast stem cells (EpiSCs) are derived from the post-implantation epiblast and are characterized by a restricted developmental potential. Although certain mouse strains, such as the non-obese d...
ORGANISM(S): Mus musculus 
2009-04-09 | E-GEOD-15603 | biostudies-arrayexpress
ProteomicsNOD Mouse Islet Peptide Content Identification
Beta-cells produce hybrid insulin peptides (HIPs) by linking insulin fragments to other peptides through peptide bonds. HIPs have unique amino acid sequences and are targeted by autoreactive T cells in type 1 diabetes (T1D). Individuals with recent-onset T1D have significantly higher levels of HIP-r...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-16 | PXD041616 | Pride
Hips Nod mouse Islet cells Peptides Lc-msms 
TranscriptomicsThe NOD/SCID Xenograft Model Provides Clinically-Relevant Insights into Glucocorticoid-Induced Gene Expression in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia
Introduction. Glucocorticoids are critical drugs used to treat acute lymphoblastic leukemia, and response to glucocorticoids is highly predictive of outcome. Here we report a study evaluating the NOD/SCID xenograft mouse model to investigate glucocorticoid-induced gene expression. Methods. NOD/SCID ...
ORGANISM(S): Homo sapiens 
2011-11-28 | E-GEOD-30392 | biostudies-arrayexpress
TranscriptomicsGene expression in the pancreatic lymph nodes (PLN) of hyperglycemic 16-week-old Non-Obese Diabetic (NOD) mice compared to expression the PLN of euglycemic 16-week-old NOD mice.
These experiments were performed to identify differentially expressed genes in the pancreatic lymph nodes of hyperglycemic NOD mice with high levels of destructive insulitis compared to euglycemic mice with lower levels of insulitis. The pancreatic lymph nodes of 16-week-old hyperglycemic and euglyc...
ORGANISM(S): Mus musculus 
2014-06-01 | E-GEOD-57237 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of CD4+CD25+ Tregs from NOD and B6.H2g7 mice
The NOD (nonobese diabetic) mouse strain develops a characteristic autoimmune syndrome that closely resembles human type I diabetes. It has been suggested that NOD mice exhibit both numerical deficiency in CD4+CD25+ regulatory T cells (Treg) and reduced suppressive activity. We compared sorted CD4...
ORGANISM(S): Mus musculus 
2008-12-19 | E-GEOD-6813 | biostudies-arrayexpress
TranscriptomicsGene expression in the isolated islets of 10 day old, 4 wk old, 12 wk old, and 20 wk old Non-Obese Diabetic (NOD) mice compared to healthy age matched control NOD.B10 mice
Gene expression in the islets of diseased NOD mice compared to congenic healthy NOD.B10 mice at various ages, during the progression of NOD disease. Islets were isolated from individual NOD and NOD.B10 mice by collagenase digestion. RNA was extracted using Trizol, combined with the RNeasy micro kit ...
ORGANISM(S): Mus musculus 
2013-11-28 | E-GEOD-52815 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse total pancreatic RNA from 3 week old NOD.scid, NOD, BDC2.5/NOD and BDC2.5/NOD.scid animals
Total pancreatic RNA was isolated from 3 week old NOD.scid, NOD, BDC2.5/NOD and BDC2.5/NOD.scid animals by GITC method. Targets were produced using standard Affymetrix procedures from about 10ug total RNA. The data from NOD.scid, NOD, BDC2.5/NOD and BDC2.5/NOD.scid Affymetrix MGU74Av2 cel files was ...
ORGANISM(S): Mus musculus 
2007-10-12 | E-GEOD-1623 | biostudies-arrayexpress
TranscriptomicsGene expression in the islets of 12 wk old Non-Obese Diabetic (NOD) mice and healthy control NOD.B10 mice
Gene expression in the islets of NOD and NOD.B10 mice at 12 weeks of age, prior to the onset of destructive insulitis. The pancreata of NOD and NOD.B10 mice (n=6) were frozen and islets were isolated by laser capture microdissection. Cryosections (8 M-NM-
ORGANISM(S): Mus musculus 
2013-04-10 | E-GEOD-45897 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in the Lacrimal gland during development and onset of xerostomia in Sjogren's syndrome-like disease of the C57BL/6.NOD-Aec1Aec2 mouse.
Recently, we reported the development of the C57BL/6.NOD-Aec1Aec2 mouse that carries two genetic intervals derived from the NOD mouse capable of conferring Sjogren's syndrome (SjS)-like disease in SjS-non-susceptible C57BL/6 mice. In an attempt to define the molecular bases underlying onset of stoma...
ORGANISM(S): Mus musculus 
2013-06-25 | E-GEOD-48139 | biostudies-arrayexpress
ProteomicsPancreatic beta cell proteome with increased proliferation in NOD mice
We investigated the pancreatic beta cell proteome changes in NOD-LIRKO vesus NOD where beta cell mass was enhanced early in life. Proteomics data is derived from FACS-sorted beta cells at 8 weeks and 12 weeks.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-03-14 | MSV000083576 | MassIVE
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