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ProteomicsStreamlined identification of permissive non-canonical amino acid incorporation sites in mammalian cell lines with an expanded genetic code
The genetic code of mammalian cells can be expanded to allow the incorporation of non-canonical amino acids (ncAAs) by suppressing in-frame amber stop codons (UAG) with an orthogonal pyrrolysyl-tRNA synthetase (PylRS)/tRNAPylCUA (PylT) pair. However, the feasibility of this approach is substantially...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-02-23 | PXD019815 | Pride
Genetic code expansion Unnatural amino acids Non-canonical amino acids Amber suppression 
ProteomicsCell-specific non-canonical amino acid labelling identifies changes in the hippocampal de novo proteome during memory formation
The formation of spatial long-term memory (LTM) requires the de novo synthesis of distinct sets of proteins; however, a non-biased examination of the de novo proteome in this process is lacking. Here, we generated a novel mouse strain, which enables cell-type-specific labelling of newly synthesised ...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD015820 | Pride
Long-term memory Non-canonical amino acid labelling Azidohomoalanine Azidonorleucine Swath Active place avoidance Protein synthesis Mrna splicing 
UnknownNon-Canonical Amino Acids in Analyses of Protease Structure and Function.
Not available
S-EPMC10531186 | biostudies-literature
TranscriptomicsTranscription profiling of wild type Halobacterium salinarum R1 growing with or without aromatic amino acids
Medium-adapted cultures of H. salinarum were grown in synthetic medium with or without AroAA, and cells harvested by centrifugation after growth had reached OD600nm=0.2 and 0.58, respectively.
ORGANISM(S): Halobacterium salinarum 
2014-12-01 | E-MEXP-3818 | biostudies-arrayexpress
UnknownNon-Canonical Amino Acids as Building Blocks for Peptidomimetics: Structure, Function, and Applications.
Not available
S-EPMC10296201 | biostudies-literature
UnknownSynthesis of non-canonical amino acids through dehydrogenative tailoring.
Not available
S-EPMC11904927 | biostudies-literature
UnknownBifunctional Non-Canonical Amino Acids: Combining Photo-Crosslinking with Click Chemistry.
Not available
S-EPMC7226127 | biostudies-literature
UnknownIncorporation of non-canonical amino acids into the developing murine proteome.
Not available
S-EPMC5004113 | biostudies-literature
ProteomicsUncover New Reactivity of Genetically Encoded Alkyl Bromide Unnatural Amino Acids
Genetically encoded unnatural amino acids (Uaas) with electrophilic moieties are excellent tools to investigate protein-protein interactions (PPIs) both in vitro and in vivo. These Uaas, including a series of alkyl bromide-based Uaas, mainly target cysteine residues to form protein-protein cross-lin...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2022-04-04 | PXD031159 | Pride
Chemical cross-linking And sumo interactome Unnatural amino acid Protein-protein interactions Genetic code expansion 
UnknownPepLand: a large-scale pre-trained peptide representation model for a comprehensive landscape of both canonical and non-canonical amino acids.
Not available
S-EPMC12315545 | biostudies-literature
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