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ProteomicsMECOM: A novel player in AR-driven Treatment Resistant Castration-Resistant Prostate Cancer
Reprogramming of the androgen receptor (AR) cistrome is associated with disease progression, and advanced castrate-resistant prostate cancers (CRPC) tend to rely on a reprogrammed/non-canonical AR signaling that is addictive to AR signaling inhibitor (ARSI) resistance. We identified EVI1, an oncogen...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD062331 | Pride
Mecom Epigenetics Castration-resistance Drug resistance Parpi Prostate cancers Enzalutamide-resistance Androgen receptor Evi1-mds1 complex Non-canonical ar 
GenomicsRedefinition of Human Androgen Responsive Elements [MNase-Seq, ChIP_seq]
The androgen receptor (AR) mediates the action of androgens by binding to androgen-responsive elements (AREs) and subsequently regulating target genes involved in prostate carcinogenesis. The precise locations, true nature, and functional roles of AREs in human prostate cancer are still unknown. Her...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-43720 | biostudies-arrayexpress
TranscriptomicsCanonical and non-canonical regulatory roles of androgen receptor variant 7 in prostate cancer
The androgen receptor splice variant 7 (AR-V7) lacks the ligand-binding domain; is detected with increased frequency in advanced prostate cancer and is postulated to be one crucial mechanism for disease progression and therapeutic resistance to androgen deprivation in castration–resistant prostate c...
ORGANISM(S): Homo sapiens 
2018-10-02 | GSE94013 | GEO
GenomicsRedefinition of Human Androgen Responsive Elements [FOX_ChIP_exo]
The androgen receptor (AR) mediates the action of androgens by binding to androgen-responsive elements (AREs) and subsequently regulating target genes involved in prostate carcinogenesis. The precise locations, true nature, and functional roles of AREs in human prostate cancer are still unknown. Her...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-43678 | biostudies-arrayexpress
UnknownSrc promotes castration-recurrent prostate cancer through androgen receptor-dependent canonical and non-canonical transcriptional signatures.
Not available
S-EPMC5354662 | biostudies-literature
GenomicsAndrogen receptor variant 7 non-canonical genome integrity functions in prostate cancer
Androgen receptor variant 7 non-canonical genome integrity functions in prostate cancer
PRJNA885013 | ENA
ProteomicsThe Expanding Landscape of Human Protein Phosphorylation C4PR_LIV
Investigation of protein phosphorylation in humans has largely focussed on serine (Ser), threonine (Thr) and tyrosine (Tyr), with proven roles for these modifications in all aspects of life. However, mounting evidence suggests that phosphorylation of non-canonical amino acids, including histidine an...
ORGANISM(S): Homo sapiens (Human) 
2020-06-16 | PXD012188 | Pride
Strong anion exchange Phosphoaspartate Non-canonical phosphorylation Phosphoproteomics Mass spectrometry 
GenomicsNon-canonical functions of UGT2B17 promote castrate-resistant prostate cancer progression
Non-canonical functions of UGT2B17 promote castrate-resistant prostate cancer progression
PRJNA1241290 | ENA
GenomicsNon-canonical functions of UGT2B17 promote castrate-resistant prostate cancer progression
Non-canonical functions of UGT2B17 promote castrate-resistant prostate cancer progression
PRJNA1241122 | ENA
UnknownAR-V7 exhibits non-canonical mechanisms of nuclear import and chromatin engagement in castrate-resistant prostate cancer.
Not available
S-EPMC9398446 | biostudies-literature
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