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ProteomicsImmunogenicity of non-canonical HLA-I tumor ligands identified through proteogenomics
Tumor antigens are central to antitumor immunity. Recent evidence suggests that peptides from non-canonical (nonC) aberrantly translated proteins can be presented on HLA-I by tumor cells. Here, we investigated the presentation and immunogenicity of nonC antigens across different cancer types to bett...
ORGANISM(S): Homo sapiens (Human) 
2023-02-03 | PXD036856 | Pride
Human Non-canonical hla-i ligands 
ProteomicsThe HLA-Ligand-Atlas. A resource of natural HLA ligands presented on benign tissues
The human leukocyte antigen (HLA) complex regulates the adaptive immune response by showcasing the intracellular and extracellular protein content to the immune system. T cells recognize these HLA-presented peptides as self or foreign and can elicit an immune response. In this work, we describe the...
ORGANISM(S): Homo sapiens (Human) 
2021-04-16 | PXD019643 | Pride
Human Hla Benign tissues Immunopeptidomics 
ProteomicsThe HLA-Ligand-Atlas. A resource of natural HLA ligands presented on benign tissues
The human leukocyte antigen (HLA) complex regulates the adaptive immune response by showcasing the intracellular and extracellular protein content to the immune system. T cells recognize these HLA-presented peptides as self or foreign and can elicit an immune response. In this work, we describe the...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-31 | MSV000096271 | MassIVE
ProteomicsTumor-associated peptides can be detected from the plasma-derived soluble immunopeptidome in human hepatocellular carcinoma patients – A pre-clinical study on the correlation of the soluble and hepatocellular carcinoma-derived membranous immunopeptidomes.
Abstract Background and aims. Hepatocellular carcinoma (HCC) shows limited response to checkpoint inhibitors, leaving opportunity for antigen-based immunotherapy and improved disease monitoring. This study evaluates plasma-derived soluble HLA-I (sHLA-I) peptidome as a minimally invasive source of tu...
ORGANISM(S): Homo sapiens (Human) 
2025-10-15 | PXD066255 | Pride
Hepatocellular carcinoma Immunopeptidomics Soluble hla Shla 
ProteomicsA lysine residue at the C-terminus of MHC class I ligands correlates with low C-terminal proteasomal cleavage probability
The majority of peptides presented by MHC class I results from proteasomal protein turnover. The specialized immunoproteasome, which is induced during inflammation, plays a major role in antigenic peptide generation. However, other cellular proteases can, either alone or together with the proteasome...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD044235 | Pride
Immunopeptidomics  proteasome-independent  non-canonical mhc class i ligands  hla-a*03:01  hla-a*11:01  hla-a*30:01  proteasomal cleavage probability  peptide origin  peptide processing 
ProteomicsProteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification
Systemic pan-tumor analyses may reveal the significance of common features implicated in cancer immunogenicity and patient survival. Here, we provide a comprehensive multi-omics data set for 32 patients across 25 tumor types for proteogenomic-based discovery of neoantigens. By using an optimized com...
ORGANISM(S): Homo sapiens (Human) 
2023-05-16 | PXD037655 | Pride
Proteogenomics Neoantigens Human tumor Hla class i immunopeptidomics 
ProteomicsHLA-B27 interferes with TGF-/activin signaling in Drosophila and rat transgenic models, resulting in pathogenic consequences relevant for spondyloarthritis.
Background The striking association of HLA-B27 with spondyloarthritis (SpA) has been known for 50 years. However, its pathophysiological significance remains incompletely understood. In the HLA-B27/human-β2 microglobulin (hβ2m) transgenic rat (B27 rat) that spontaneously develops inflammatory pheno...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2024-10-17 | PXD047119 | Pride
Hla peptidome Spondyloarthritis  bmp/tgfβ pathway  hla-b27  cd4+ t cells  rat  drosophila 
UnknownNaturally processed non-canonical HLA-A*02:01 presented peptides.
Not available
S-EPMC4317018 | biostudies-literature
UnknownReleasing the concept of HLA-allele specific peptide anchors in viral infections: A non-canonical naturally presented human cytomegalovirus-derived HLA-A*24:02 restricted peptide drives exquisite immunogenicity.
Not available
S-EPMC6593758 | biostudies-literature
UnknownHLA Ligand Atlas: a benign reference of HLA-presented peptides to improve T-cell-based cancer immunotherapy.
Not available
S-EPMC8054196 | biostudies-literature
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