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ProteomicsProteomic and bioinformatic characterization of proteins secreted conventionally and unconventionally from human primary macrophages upon LPS transfection
The non-canonical caspase-4/5 inflammasome has been only very recently characterized. It is expressed by macrophages, the principal effector cells of the innate immunity system, and is activated by gram-negative bacteria, ER stress, and UV radiation. Activation of this inflammasome results in pyropt...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080769 | MassIVE
ProteomicsTLR4 activation primes human macrophages for non-canonical caspase-4 inflammasome-induced extracellular vesicle secretion
Human macrophages secrete extracellular vesicles loaded with numerous immunoregulatory proteins. Here we employed high throughput quantitative proteomics to characterize the modulation of vesicle-mediated protein secretion during non-canonical caspase-4/5-dependent inflammasome activation. We show t...
ORGANISM(S): Homo sapiens (Human) 
2022-12-01 | PXD033002 | Pride
Caspase-4 Macrophages Proteomics Extracellular vesicles Interferon Non-canonical inflammasome 
GenomicsUnanchored ubiquitin chains promote the non-canonical inflammasome via UBXN1
Unanchored ubiquitin chains promote the non-canonical inflammasome via UBXN1
PRJNA1311104 | ENA
ProteomicsProteomic and bioinformatic characterization of proteins secreted conventionally and unconventionally from human primary macrophages upon LPS transfection
The non-canonical caspase-4/5 inflammasome has been only very recently characterized. It is expressed by macrophages, the principal effector cells of the innate immunity system, and is activated by gram-negative bacteria, ER stress, and UV radiation. Activation of this inflammasome results in pyropt...
ORGANISM(S): Homo sapiens (Human) 
2017-03-07 | PXD005083 | Pride
Lps Innate immunity Non-canonical inflammasome Macrophages 
ProteomicsHyperactivity of the non-canonical inflammasome promotes neuroinflammation in Hereditary Spastic Paraplegia type SPG11 and SPG48
Hereditary spastic paraplegia (HSP) is characterized by a spastic gait disorder due to degeneration of corticospinal axons. The genetics of this disease is highly heterogeneous with more than 80 different genes involved which are denoted as SPGs. Variants in SPG11 are responsible for the most common...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-11 | PXD065699 | Pride
Neuroinflammation Bone marrow derived macrophages Spg48 Spg11 
UnknownMercury and arsenic attenuate canonical and non-canonical NLRP3 inflammasome activation.
Not available
S-EPMC6135747 | biostudies-literature
UnknownHepatocytes Are Resistant to Cell Death From Canonical and Non-Canonical Inflammasome-Activated Pyroptosis.
Not available
S-EPMC8783146 | biostudies-literature
UnknownMethylene blue inhibits NLRP3, NLRC4, AIM2, and non-canonical inflammasome activation.
Not available
S-EPMC5622101 | biostudies-literature
UnknownNon-canonical inflammasome activation mediates the adjuvanticity of nanoparticles.
Not available
S-EPMC9873954 | biostudies-literature
UnknownHyperactivity of the non-canonical inflammasome in SPG11 and SPG48.
Not available
S-EPMC12595280 | biostudies-literature
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