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ProteomicsHyperactivity of the non-canonical inflammasome promotes neuroinflammation in Hereditary Spastic Paraplegia type SPG11 and SPG48
Hereditary spastic paraplegia (HSP) is characterized by a spastic gait disorder due to degeneration of corticospinal axons. The genetics of this disease is highly heterogeneous with more than 80 different genes involved which are denoted as SPGs. Variants in SPG11 are responsible for the most common...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-11 | PXD065699 | Pride
Neuroinflammation Bone marrow derived macrophages Spg48 Spg11 
UnknownHyperactivity of the non-canonical inflammasome in SPG11 and SPG48.
Not available
S-EPMC12595280 | biostudies-literature
UnknownComplicated spastic paraplegia in patients with AP5Z1 mutations (SPG48).
Not available
S-EPMC5001803 | biostudies-literature
UnknownAP5Z1/SPG48 frequency in autosomal recessive and sporadic spastic paraplegia.
Not available
S-EPMC4190872 | biostudies-literature
UnknownInhibiting mitochondrial fission rescues degeneration in hereditary spastic paraplegia neurons.
Not available
S-EPMC10200290 | biostudies-literature
UnknownImpaired mitochondrial dynamics underlie axonal defects in hereditary spastic paraplegias.
Not available
S-EPMC6031053 | biostudies-literature
UnknownChildhood-onset hereditary spastic paraplegia and its treatable mimics.
Not available
S-EPMC8843241 | biostudies-literature
TranscriptomicsTranscription profiling of human chronic lymphocytic leukemia patients expressing high or low levels of ZAP70 mRNA
Comparison of Chronic Lymphocytic Leukemia patients expressing high or low levels of ZAP70 mRNA: prognostic factors and interaction with the microenvironment. Zeta-associated protein 70 (ZAP70) is a widely recognized prognostic factor in chronic lymphocytic leukemia (CLL), but mechanisms by which it...
ORGANISM(S): Homo sapiens 
2009-04-25 | E-GEOD-12734 | biostudies-arrayexpress
TranscriptomicsBroad, ectopic expression of the sperm protein, PLCZ1 induces parthenogenesis and ovarian tumours in mice
Mammalian metaphase II (mII) exit and embryogenesis are induced at fertilization by a signal thought to come from the sperm protein, phospholipase C-zeta (PLCZ1). Meiotic progression can also be triggered without sperm, as in parthenogenesis, although the classic mouse in vivo parthenogenetic model...
ORGANISM(S): Mus musculus 
2007-10-01 | E-GEOD-4822 | biostudies-arrayexpress
TranscriptomicsIdentification of in vivo, conserved, TAF15 RNA binding sites and the impact of TAF15 on the neuronal transcriptome
TAF15, an RNA binding protein was recently implicated in Amyotrophic Lateral Sclerosis (ALS). ALS is a fatal neurodegenerative disease. We report the identification of the conserved neuronal RNA targets of TAF15 and the assessment of the impact of TAF15 depletion on the neuronal transcriptome. Our ...
ORGANISM(S): Mus musculus 
2013-01-24 | E-GEOD-43294 | biostudies-arrayexpress
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