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Background: Autism spectrum disorder (ASD) is defined as a pervasive developmental disorder which is caused by genetic and environmental risk factors. Besides the core behavioral symptoms, accumulated results indicate children with ASD also share some metabolic abnormalities. Objectives:
2022-03-02 | MTBLS2421 | MetaboLights
In our attempts to profile different regulators of the WNT/b-catenin transcriptional complex, CUT&RUN failed to produce consistent binding patterns of the non-DNA-binding b-catenin. We developed a modified CUT&RUN protocol, which we refer to as LoV-U (Low Volume and Urea), that enables the generatio...
ORGANISM(S): Mus musculus 
Wnt/β-catenin signaling is a highly organized biochemical cascade that triggers a gene expression program in the signal-receiving cell. The Wnt/β-catenin-driven transcriptional response is involved in virtually all cellular processes during development, homeostasis, and its deregulation causes human...
ORGANISM(S): Homo sapiens 
Understanding how gene regulators bind DNA and interact with one another is essential for understanding gene expression, yet existing technologies typically measure either chromatin occupancy or protein–protein interactions in isolation, require high cell numbers, and/or depend on genetic engineerin...
ORGANISM(S): Homo sapiens (Human) 
2026-10-05 | PXD071610 | Pride
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