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MetabolomicsPFKFB3-mediated glycolysis boosts fibroblast activation and subsequent kidney fibrosis

Renal fibrosis, a hallmark of chronic kidney diseases, is driven by the activation of renal fibroblasts. Recent studies have highlighted the role of glycolysis in this process. Nevertheless, one critical glycolytic activator, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), remain...

2024-03-12 | MTBLS8281 | MetaboLights
MetabolomicsMetabolic analysis of Normal Mouse Lung Fiboblasts with/without TGFbeta treatment
Not available
ORGANISM(S): Mus musculus 
ST000827 | MetabolomicsWorkbench
MetabolomicsMetabolic analysis of Normal Mouse Lung Fiboblasts with/without TGFbeta treatment (Part 1)
Not available
ORGANISM(S): Mus musculus 
ST000143 | MetabolomicsWorkbench
TranscriptomicsExpression data of the iPSCs derived from foreskin fibroblast cells of normal person and KS patient
Klinefelter’s Syndrome (KS) is one of the common chromosome aneuploidy diseases in males with unexplained physiological mechanism. iPSCs, are similar to ESCs in terms of indefinitive self-renewal and pluripotency, provided an alternative choice for modeling disease to facilitate the disease research...
ORGANISM(S): Homo sapiens 
2012-04-13 | E-GEOD-37258 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human fibroblasts from the stroma of squamous cell carcinoma and normal dermal fibroblasts
Head and neck squamous cancer stromal fibroblasts produce growth factors influencing phenotype of normal human keratinocytes. Epithelial-mesenchymal interaction between stromal fibroblasts and cancer cells influences the functional properties of tumor epithelium including the tumor progression and s...
ORGANISM(S): Homo sapiens 
2009-12-31 | E-MTAB-97 | biostudies-arrayexpress
ProteomicsComprehensive Proteomic Profiling of Converted Adipocyte-like Cells from Normal Human Dermal Fibroblast using Data-Independent Acquisition Mass Spectrometry (DIA-MS)
We applied direct conversion of normal human dermal fibroblast (NHDF) into adipocyte-like cells using adipogenic cocktail containing IBMX, dexamethasone, insulin, and rosiglitazone and confirmed prominent lipid droplet accumulation in the converted cells for proteomic research
ORGANISM(S): Homo sapiens (Human) 
2025-05-13 | PXD050528 | Pride
Adipocyte-like cells Dia-ms Mass spectrometry Proteomics Extracellular proteome Normal human dermal fibroblast Intracellular proteome. 
TranscriptomicsThe effects of RED GREEN and BLUE LED light on human normal healthy fibroblast cell lines
The purpose of this study is to investigate whether LED light at different wavelength can improve wound healing in normal fibroblast. In this study, both diabetic and normal fibroblast cell lines were cultured and created some artificial wounds with pipette tips. After LED irradiation and microarray...
ORGANISM(S): Homo sapiens 
2016-02-18 | E-GEOD-78018 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of normal and Mucopolysaccharidosis type VI rat fibroblast-like synoviocytes
Gene expression in 9 month-old Mucopolysaccharidosis type VI rat fibroblast-like synoviocytes (FLS) were compared to age-matched normal rat FLS
ORGANISM(S): Rattus norvegicus 
2007-10-24 | E-TABM-306 | biostudies-arrayexpress
TranscriptomicsTwist1 gain-of-function studied in 2 normal gastric fibroblast lines
Primary human gastric normal fibroblast cultures (NL14 and NL32, repectivley) were establised from 2 gastrectomy specimens. Enforced expression (gain-of-function effect) of Twist1 in 2 gastric normal fibroblasts (NL14 and NL32) showed candidate target genes and CAF markers upregulated by Twist1. Exp...
ORGANISM(S): Homo sapiens 
2014-10-28 | E-GEOD-62739 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of fibroblast-like synovial cells from normal adult horse following treatment with hyaluronan and challenged with lipopolysaccharide
Greater than 95% confluent (Day 0) fibroblast-like synovial cells from the hind limbs (pelvic limb) of normal adult horses were allocated in triplicate to one of 4 groups:

(group 1) unchallenged;
(group 2) LPS-challenged;
(group 3) LPS-challenged following pre-treatment and susta...
ORGANISM(S): Equus caballus 
2007-01-10 | E-MEXP-940 | biostudies-arrayexpress
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