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TranscriptomicsExpression data from oral squamous cell carcinoma (OSCC)-derived cell lines and normal oral keratinocytes
Oral squamous cell carcinoma (OSCC) is a lethal disease and early death usually occurs as a result of local invasion and regional lymph node metastases. We used microarrays to identify down or upregulated genes in OSCCs compared with non-malignant controls. To identify genes whose transcription is d...
ORGANISM(S): Homo sapiens 
2011-09-01 | E-GEOD-31853 | biostudies-arrayexpress
TranscriptomicsMolecular effects of EtOH and Nicotine on normal human oral keratinocytes
We have performed gene expression microarry analysis to profile molecular alterations in normal human oral keratinocytes that are induced by EtOH and/or nicotine. Our goal is to examine molecular signatures that are dysregulated by EtOH or nicotine and define the effects of co-use of alcohol and nic...
ORGANISM(S): Homo sapiens 
2014-05-14 | E-GEOD-57634 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human normal and transformed buccal keratinocytes
Normal and two transformed buccal keratinocyte lines were cultured under a standardized condition to explore mechanisms of carcinogenesis and tumor marker expression at transcript and protein level. An approach combining three bioinformatic programs allowed coupling of abundant proteins and large-sc...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7862 | biostudies-arrayexpress
GenomicsGene expression analysis of normal oral keratinocytes cells and oral squamous cell carcinoma (OSCC) cells
Gene expression analysis of normal oral keratinocytes cells and oral squamous cell carcinoma (OSCC) cells
PRJNA1092091 | ENA
ProteomicsChronic shisha exposure alters phosphoproteome of oral keratinocytes
Shisha smoking has been epidemiologically linked to development of oral lesions as well as various cancers. However, few molecular studies investigate the pathobiology of shisha induced cancer. In this study we investigate the effects of chronic shisha exposure in an in vitro model using normal, imm...
ORGANISM(S): Homo sapiens (Human) 
2019-07-23 | PXD011318 | Pride
Oral cancer Hookah Waterpipe tobacco smoking Narghile tobacco Carcinogenesis High-throughput Oscc Orbitrap fusion 
GenomicsEpigenome analysis of normal oral keratinocytes cells and oral squamous cell carcinoma (OSCC) cells
Epigenome analysis of normal oral keratinocytes cells and oral squamous cell carcinoma (OSCC) cells
PRJNA1091316 | ENA
ProteomicsSecretome analysis of oral keratinocytes chronically exposed to shisha
Shisha smoking has been associated with multiple diseases including oral cancer. However, a mechanistic study to investigate alteration of secreted proteins in oral cells due to shisha smoking is lacking. Elucidation of differentially secreted proteins by immortalized human normal oral keratinocyte...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD011130 | Pride
Tmt Okf6/tert1 Oral cancer Secretome Waterpipe Proteomics 
ProteomicsProteomic analysis of oral keratinocytes chronically exposed to shisha
Shisha smoking is widely believed to be a hazard-free habit. Studies have reported shisha smoking to be associated with oral lesions as well ascarcinomas of the lung, esophagus, bladder, and pancreas. A better understanding of the underlying mechanism may contribute to the identification of biomarke...
ORGANISM(S): Homo sapiens (Human) 
2019-02-21 | PXD011106 | Pride
Immune response Interferon pathway Proteomics Oxidative stress In vitro cellular model 
TranscriptomicsComparative analysis of mouse oral cancer cell lines
A comparative microarray analysis of indolent or aggressive mouse oral cancer cell lines was performed to identify gene expression signatures and specific molecules involved in aggressive tumor growth. We compared 3 indolent cell lines (MOC1, MOC22, MOC23) to 1 aggressive line and it's derivatives ...
ORGANISM(S): Mus musculus 
2014-04-13 | E-GEOD-50041 | biostudies-arrayexpress
ProteomicsMolecular alterations elicited by chronic exposure to cigarette smoke and chewing tobacco in oral keratinocytes
Tobacco is mainly consumed in two different forms (smoking and chewing) that vary in their composition and methods of intake. Despite being the leading cause of oral cancer, the molecular mechanisms resulting in malignancy upon tobacco exposure are yet to be fully elucidated. We therefore sought to ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-08 | PXD007127 | Pride
Chronic exposure Orbitrap fusion Carcinogenesis High-throughput Smoking 
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