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ProteomicsSecretome analysis of oral keratinocytes chronically exposed to shisha
Shisha smoking has been associated with multiple diseases including oral cancer. However, a mechanistic study to investigate alteration of secreted proteins in oral cells due to shisha smoking is lacking. Elucidation of differentially secreted proteins by immortalized human normal oral keratinocyte...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD011130 | Pride
Tmt Okf6/tert1 Oral cancer Secretome Waterpipe Proteomics 
ProteomicsProteomic analysis of oral keratinocytes chronically exposed to shisha
Shisha smoking is widely believed to be a hazard-free habit. Studies have reported shisha smoking to be associated with oral lesions as well ascarcinomas of the lung, esophagus, bladder, and pancreas. A better understanding of the underlying mechanism may contribute to the identification of biomarke...
ORGANISM(S): Homo sapiens (Human) 
2019-02-21 | PXD011106 | Pride
Immune response Interferon pathway Proteomics Oxidative stress In vitro cellular model 
ProteomicsMolecular alterations elicited by chronic exposure to cigarette smoke in oral keratinocytes
Smoking is the leading cause of preventable death worldwide. It increases the risk for various diseases including respiratory diseases, vascular diseases and different cancers including lung, oral and bladder cancer. Despite being the leading cause of oral cancer, the molecular mechanisms resulting ...
ORGANISM(S): Homo sapiens (Human) 
2018-03-05 | PXD007637 | Pride
Chronic exposure Orbitrap fusion Carcinogenesis High-throughput Smoking 
ProteomicsChronic exposure to chewing tobacco induces growth in normal oral cells via overexpression of Stearoyl-CoA desaturase
The practice of using chewing tobacco is common in certain socio-economic sections of southern Asia particularly in the Indian subcontinent. The molecular mechanism of smokeless tobacco which leads to malignancy is unclear. Chewing tobacco demonstrates a carcinogenic effect through chronic and not a...
ORGANISM(S): Homo sapiens (Human) 
2016-12-14 | PXD001554 | Pride
Chewing tobacco Head and neck squamous cell carcinoma Quantitative proteomics 
ProteomicsChronic shisha exposure alters phosphoproteome of oral keratinocytes
Shisha smoking has been epidemiologically linked to development of oral lesions as well as various cancers. However, few molecular studies investigate the pathobiology of shisha induced cancer. In this study we investigate the effects of chronic shisha exposure in an in vitro model using normal, imm...
ORGANISM(S): Homo sapiens (Human) 
2019-07-23 | PXD011318 | Pride
Oral cancer Hookah Waterpipe tobacco smoking Narghile tobacco Carcinogenesis High-throughput Oscc Orbitrap fusion 
ProteomicsIdentification of potential biomarkers of head and neck squamous cell carcinoma using iTRAQ based quantitative proteomic approach
Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers in India. Despite improvements in treatment strategy, the survival rates of HNSCC patients remains poor. Thus, it is necessary to identify biomarkers that can be used for early detection of disease. In this study, we emp...
ORGANISM(S): Homo sapiens (Human) 
2018-09-19 | PXD009241 | Pride
Mass spectrometry Hnscc Parallel reaction monitoring Itraq Okf6/tert 
ProteomicsDysregulation of splicing proteins in head and neck squamous cell carcinoma
Aberrant activation of splicing regulators contributes to oncogenic transformation of cells by modulating the alternative splicing events of key oncogenes. Phosphorylation of splicing factors affects subcellular localization and activity of these proteins. Studies have shown a close association betw...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD001862 | Pride
Head and neck squamous cell carcinoma Splicing Phosphoproteomics 
ProteomicsDYRK1A, a potential therapeutic target for head and neck squamous cell carcinoma
To identify the activated tyrosine kinase signaling pathways in HNSCC, we carried out phosphotyrosine profiling using a panel of HNSCC cell lines compared to a normal oral keratinocyte. A total of 61 unique phosphosites were identified across these cell lines. Dual-specificity tyrosine-(Y)-phosphor...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD002132 | Pride
Dual specificity kinases Head and neck squamous cell carcinoma Phosphoproteomics 
UnknownChronic shisha exposure alters phosphoproteome of oral keratinocytes.
Not available
S-EPMC6732141 | biostudies-literature
UnknownMolecular alterations associated with chronic exposure to cigarette smoke and chewing tobacco in normal oral keratinocytes.
Not available
S-EPMC6154853 | biostudies-literature
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