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GenomicsSearch for new loci and low-frequency variants influencing glioma risk by exome-array analysis
To identify protein altering variants (PAVs) for glioma we analysed Illumina HumanExome BeadChip exome array data on 1,882 glioma cases and 8,079 controls from three independent European populations. In addition to single variant tests we incorporated information on the predicted functional conseque...
EGAS00001001258 | EGA
GenomicsSummary statistics from genome-wide association study in glioma of 12,488 cases and 18,169 controls.
Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,488 cases and 18,169 controls. We identified five ...
EGAS00001003372 | EGA
TranscriptomicsTranscription profiling of human haematological neoplasias from blood samples and cell lines
Validation of a custom low density microarray. Gene expression differences were analysed in the following groups of blood samples and cell lines:
Two haematological neoplasia cell lines: U937 (promonocytic lymphoma) versus Jurkat (T leukemia).
Different types of haematological neoplasias: heal...
ORGANISM(S): Homo sapiens 
2007-01-31 | E-TABM-87 | biostudies-arrayexpress
TranscriptomicsSuppression of breast tumor growth and metastasis by an engineered transcription factor
Abstract Maspin is a tumor and metastasis suppressor playing an essential role as gatekeeper of tumor progression. It is highly expressed in epithelial cells but is silenced in the onset of metastatic disease by epigenetic mechanisms. Reprogramming of Maspin epigenetic silencing offers a therapeutic...
ORGANISM(S): Homo sapiens 
2011-08-22 | E-GEOD-27842 | biostudies-arrayexpress
GenomicsNational Institute on Aging (NIA) SardiNIA Study

Sardinia is the second largest island in the Mediterranean and constitutes a genetically isolated founder population. This population has aided in the identification of genes involved in several Mendelian disorders and is attractive for genetic studies due to its organization in long-establishe...

phs000338.v1.p1 | EGA
GenomicsSardiNIA Medical Sequencing Discovery Project

The SardiNIA Medical Sequencing Discovery Project is a study of the genetics of blood lipid levels and personality in a Sardinian population cohort. The project will generate draft genome sequences for 1,000 individuals using whole genome shotgun sequencing. The draft sequences will allow investi...

phs000313.v3.p2 | EGA
TranscriptomicsTranscription profiling of mouse mECK36: a cell and animal model of virally induced Kaposis sarcoma
Transfection of a Kaposi's sarcoma (KS) herpesvirus (KSHV) Bacterial Artificial Chromosome (KSHVBac36) into mouse bone marrow endothelial lineage cells generated a cell (mECK36) that induced KS-like tumors in mice. mECK36 formed KSHV-harboring vascularized spindle-cell sarcomas that were LANA+ and d...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6482 | biostudies-arrayexpress
TranscriptomicsThe response of Desulfotomaculum reducens MI-1 to U(VI) exposure: a transcriptomic study
Desulfotomaculum reducens is the first Gram-positive sulfate- and metal- reducing bacterium for which the transcriptomic response to uranium exposure has been evaluated. The genes upregulated during fermentative growth in the presence of U(VI) as compared to its absence included those encoding for p...
ORGANISM(S): Desulfotomaculum reducens MI-1 
2010-07-15 | E-GEOD-22944 | biostudies-arrayexpress
TranscriptomicsGeneration of tumor initiating cells by exogenous delivery of OCT4 transcription factor
Introduction: Tumor initiating cells (TICs) are being extensively studied for their role in tumor etiology, maintenance and resistance to treatment. The isolation of TICs has been limited by the scarcity of this population in the tissue of origin and because the molecular signatures that characteriz...
ORGANISM(S): Homo sapiens 
2011-08-16 | E-GEOD-26539 | biostudies-arrayexpress
GenomicsGlioma_Exome_UK_CASES - samples
UK glioma case germline genotypes using Illumina HumanExome-12v1_A array
EGAD00010000754 | EGA
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