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ProteomicsCharacterisation of corneal defects in ATG7-deficient mice
Proteomic analysis of mouse cornea lysates. ATG7 is an autophagy component necessary for thedegradation and recycling of cellular components. We aim to characterise the difference in corneal phenotype between an ATG7 knockdown mouse model and a control mouse model.
ORGANISM(S): Mus musculus (Mouse) 
2025-11-10 | PXD068453 | Pride
Cornea  autophagy  limbal stem cells  proteomics 
ProteomicsABCB5+ limbal epithelial stem cells inhibit developmental, but promote inflammatory (lymph)angiogenesis while preventing corneal inflammation
ABCB5 is marker for Limbal epithilal stem cells. A comparison between ABCB5+ versus ABCB5- cultured human limbal epithelial cells was carried out to evaluate the properties of the limbal stem cell ABCB5+ with a special focus on their role in inflammation and angiogenesis.
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD041004 | Pride
(lymph)angiogenesis Cornea Abcb5 Limbal epithelial stem cells 
ProteomicsShort-term UVB irradiation leads to persistent DNA damage in limbal epithelial stem cells, partially reversed by DNA repairing enzymes
Proteomic analysis of cell lysates: Our primary goal is to repair UV damage in human corneal epithelial cells using the T4N5 enzyme and to know if what the inflammatory outcomes of irradiation and/or T4 enzyme treatment are
ORGANISM(S): Homo sapiens (Human) 
2023-02-10 | PXD039928 | Pride
Cornea  uv  dna damage  limbal stem cells  proteomics 
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