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ProteomicsMapping sites of O-fucose modification on mouse NOTCH2
The O-fucose modification sites on mouse NOTCH2 were determined by mass spectral glycoproteomic site mapping. The Extracellular Domain of mouse NOTCH2 was produced in HEK293T cells in the presence or absence of the three Fringe enzymes: Lunatic fringe, Manic fringe, or Radical fringe. The protein w...
ORGANISM(S): Homo sapiens (Human) 
2020-09-11 | PXD020431 | Pride
Notch2 Egf repeats O-fucose Fringe 
TranscriptomicsTranscription profiling of human time points after induction of Notch1-IC, Notch2-IC or EBNA2 in EREB2-5 cells - detection of Notch1-IC, Notch2-IC and EBNA2 target genes in human B cells
Notch1-IC, Notch2-IC or EBNA2 have been induced in a conditionally immortalized human B cell line (EREB2-5) in order to identify similar and unique target genes in B cells. CAT was used as a control. Experiment Overall Design: RNA was isolated at different time points after induction of Notch1-IC, N...
ORGANISM(S): Homo sapiens 
2009-08-25 | E-GEOD-12355 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of WT and Notch2-deficient classical DC subsets
Defense against attaching and effacing (A/E) bacteria requires the sequential generation of IL-23 and IL-22 to induce protective mucosal responses. While the critical source of IL-22 has been identified as CD4+ and Nkp46+ innate lymphoid cells (ILCs), the precise source of IL-23 is unclear. Here, we...
ORGANISM(S): Mus musculus 
2013-06-01 | E-GEOD-45681 | biostudies-arrayexpress
TranscriptomicsNotch2 over expression in urinary bladder RT4V6 cell line
Notch2 in promotion of bladder cancer growth and metastasis through epithelial to mesenchymal transition (EMT), cell cycle progression and maintenance of stemness. Notch2 induced gene expression in human urinary bladder cancer was measured at three independent experiments.
ORGANISM(S): Homo sapiens 
2014-08-21 | E-GEOD-60564 | biostudies-arrayexpress
GenomicsEffect of Notch2 in chondrocytes
Effect of Notch2 in chondrocytes
PRJNA930413 | ENA
TranscriptomicsNotch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine
Dendritic cells (DCs) in tissues and lymphoid organs comprise distinct functional subsets that differentiate in situ from circulating progenitors. Tissue-specific signals that regulate DC subset differentiation are poorly understood. We report that DC-specific deletion of the Notch2 receptor caused ...
ORGANISM(S): Mus musculus 
2011-10-31 | E-GEOD-31551 | biostudies-arrayexpress
TranscriptomicsConditional ablation of the Notch2 receptor in the ocular lens
Notch signaling is essential for proper lens development, however the specific requirements of individual Notch receptors has not been previously investigated. Here we report the lens phenotypes of Notch2 conditionally mutant mice, which exhibited severe microphthalmia, reduced pupillary openings, d...
ORGANISM(S): Mus musculus 
2011-12-31 | E-GEOD-31643 | biostudies-arrayexpress
ProteomicsNotch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia
The Wnt-signalling pathway is one of the core de-regulated pathways in chronic lymphocytic leukemia (CLL), activated in a subset of patients by somatic coding mutations. Here we describe an alternative mechanism of Wnt-activation in malignant B cells, mediated by Notch2 activity in mesenchymal strom...
ORGANISM(S): Mus musculus (Mouse) 
2018-09-19 | PXD010401 | Pride
Wnt Notch Cll Plasma membrane 
GenomicsNOTCH2 mutants
NOTCH2 mutants
PRJNA967022 | ENA
GenomicsNotch2 deficiency prevents muscle atrophy induced by mechanical unloading and diabetes.
Notch2 deficiency prevents muscle atrophy induced by mechanical unloading and diabetes.
PRJNA679176 | ENA
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