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MetabolomicsNPM-ALK metabolic regulation
Not available
ORGANISM(S): Homo sapiens 
ST000016 | MetabolomicsWorkbench
ProteomicsNPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes
Nucleophosmin (NPM1) is either frequently mutated or subjected to chromosomal translocation in acute myeloid leukemia (AML). NPM protein is primarily located in the nucleus, but the recurrent NPMc+ mutation is characterized by cytoplasmic localization and leukemogenic properties. Similarly, the NPM-...
ORGANISM(S): Homo sapiens (Human) 
2019-10-18 | PXD012305 | Pride
Chromatin remodeling complexes Npm-mlf1 Leukemia Npm Proteomic Epigenetic 
Genomicsnpm
Re-sequencing of npm mutants and siblings
PRJEB32642 | ENA
TranscriptomicsGene expression profiling in acute myeloid leukemia with mutated NPM
Approximately one third of acute myeloid leukemias (AMLs) are characterized by aberrant cytoplasmic localization of Nucleophosmin (NPMc+ AML), consequent to mutations in the NPM putative nucleolar localization signal. These events are mutually exclusive with the major AML-associated chromosomal rea...
ORGANISM(S): Homo sapiens 
2012-01-05 | E-GEOD-34860 | biostudies-arrayexpress
GenomicsNPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes
NPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes
PRJNA512203 | ENA
TranscriptomicsNPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes
Nucleophosmin (NPM1) is either frequently mutated or subjected to chromosomal translocation in acute myeloid leukemia (AML). NPM protein is primarily located in the nucleus, but the recurrent NPMc+ mutation is characterized by cytoplasmic localization and leukemogenic properties. Similarly, the NPM-...
ORGANISM(S): Homo sapiens 
2019-10-17 | GSE124495 | GEO
TranscriptomicsEffect of oocyte-enriched histones Th2a, Th2b, and histone chaperone Npm on mouse iPS cell generation
Expression of key transcription factors Klf4, Oct3/4, Sox2, and c-Myc (KOSM) in embryonic stem cells can reprogram somatic cells into pluripotent cells. We found that two histone variants, TH2A and TH2B, and histone chaperone Npm enhance the KOSM-dependent generation of induced pluripotent cells (iP...
ORGANISM(S): Mus musculus 
2013-12-25 | E-GEOD-53637 | biostudies-arrayexpress
GenomicsSingle cell RNA-seq to investigate transcriptional profiles of thymic double negative T cells in WT, NPM-ALK(Tg/+) and NPM-ALK(Tg/+)Cdk6-/-Stat5b-/- mice
Single cell RNA-seq to investigate transcriptional profiles of thymic double negative T cells in WT, NPM-ALK(Tg/+) and NPM-ALK(Tg/+)Cdk6-/-Stat5b-/- mice
PRJEB95949 | ENA
TranscriptomicsSingle cell RNA-seq to investigate transcriptional profiles of thymic double negative T cells in WT, NPM-ALK(Tg/+) and NPM-ALK(Tg/+)Cdk6-/-Stat5b-/- mice
To examine transcriptional differences in thymic double negative (DN) T cells between wildtype (WT), NPM-ALK(Tg/+) and NPM-ALK(Tg/+)Cdk6-/-Stat5b-/- mice, single-cell RNA sequencing (scRNA-seq) was performed on fluorescence-activated cell sorted (FACS) DN T cells. The aim was to understand how genet...
ORGANISM(S): Mus musculus 
2026-07-24 | E-MTAB-15478 | biostudies-arrayexpress
UnknownNPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes.
Not available
S-EPMC6853375 | biostudies-literature
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