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TranscriptomicsThalidomide in Total Therapy 2 Overcomes Inferior Prognosis of Myeloma with Low Expression of the Glucocorticoid Receptor Gene NR3C1
Purpose: Because dexamethasone remains a key component of myeloma therapy, we wished to examine the correlation of baseline and relapse expression levels of the glucocorticoid receptor gene NR3C1 with other clinical features. Experimental Design: We investigated the clinical impact of gene express...
ORGANISM(S): Homo sapiens 
2012-11-05 | E-GEOD-38627 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling of NK-92, CAR NK-92, and NR3C1-knockout CAR NK-92 cells following co-culture with CEACAM5⁺ A549 lung cancer cells
CEACAM5-specific CAR NK-92 cells were engineered to target CEACAM5-expressing lung tumor cells. To study their transcriptional response during tumor engagement, parental NK-92 cells, CEACAM5-CAR NK-92 cells, hydrocortisone-treated CAR NK-92 cells, NR3C1-knockout (cortisol-resistant) CAR NK-92 cells,...
ORGANISM(S): Homo sapiens 
2025-12-18 | E-MTAB-16373 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling of CAR-NK and NR3C1-knockout CAR-NK cells exposed to hydrocortisone and hypoxia-mimicking conditions
Steroids enriched within the lung tumor microenvironment suppress the cytotoxic activity of tumor-infiltrating NK cells and intensify hypoxic stress. To model these conditions in vitro, CEACAM5-specific CAR-NK cells and NR3C1-knockout CAR-NK cells were exposed to hydrocortisone (1 µM), hypoxia-mimic...
ORGANISM(S): Homo sapiens 
2025-12-18 | E-MTAB-16367 | biostudies-arrayexpress
ProteomicsThe auophagy receptor SQSTM1/p62 mediates anti-inflammatory actions of the selective NR3C1/glucocorticoid receptor modulator compound A (CpdA) in macrophages
Glucocorticoids are widely used to treat inflammatory disorders; however, prolonged use of glucocorticoids results in side effects including osteoporosis, diabetes and obesity. Compound A (CpdA), identified as a selective NR3C1/glucocorticoid receptor (nuclear receptor subfamily 3, group C, member 1...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-11 | PXD012121 | Pride
Autophagy  autophagy receptors  cpda  glucocorticoids  inflammation  nfe2l2/nrf2  sqstm1/p62 
TranscriptomicsThe knockdown of maternal glucocorticoid receptor mRNA alters embryo development in zebrafish
In zebrafish, ovulated oocytes contain both cortisol deposited from the maternal circulation and maternal mRNA for the glucocorticoid receptor (gr mRNA), which is spread as granular structures throughout the central ooplasm. At the 1-cell stage (0.2 hpf), this transcript is relocated by streamers in...
ORGANISM(S): Danio rerio 
2011-11-16 | E-GEOD-25517 | biostudies-arrayexpress
GenomicsManipulation of NR3C1 on the expression of inflammatory transcription factors and their alternative splicing patterns
Manipulation of NR3C1 on the expression of inflammatory transcription factors and their alternative splicing patterns
PRJNA783789 | ENA
UnknownNR3C1 hypermethylation in depressed and bullied adolescents.
Not available
S-EPMC6008402 | biostudies-literature
TranscriptomicsManipulation of NR3C1 on the expression of inflammatory transcription factors and their alternative splicing patterns
NR3C1-encoding glucocorticoid receptors have dual roles as RNA-binding protein and transcription factor. Recent studies revealed that NR3C1 might play an important role in the pathogenesis of PTSD (Post-traumatic stress disorder). However, its molecular mechanism remained unclear. In the present stu...
ORGANISM(S): Homo sapiens 
2024-11-26 | GSE189587 | GEO
UnknownNR3C1-mediated epigenetic regulation suppresses astrocytic immune responses in mice.
Not available
S-EPMC12454645 | biostudies-literature
ProteomicsNG2 is a target gene of MLL-AF4 that underlies glucocorticoid resistance in infant MLL-rearranged B-ALL by regulating NR3C1 expression through interaction with FLT3
B-cell acute lymphoblastic leukemia (B-ALL) is the most common pediatric cancer, with long-term overall survival rates of 80%. However, B-ALL harboring rearrangements of the MLL gene (also known as KTM2A), hereinafter termed MLLr B-ALL, is frequently seen in infants and is associated with poor 5-yea...
ORGANISM(S): Homo sapiens (Human) 
2024-07-12 | PXD041875 | Pride
Nr3c1 Ap-1 Mll-af4 Flt3 Infant b-all Glucocorticoid resistance Ng2 
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