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ProteomicsA TFEB nuclear export signal integrates amino acid supply and glucose availability
How cells coordinate the response to fluctuating carbon and nitrogen availability required to maintain effective homeostasis is a key issue. Amino acid limitation that inactivates mTORC1 promotes de-phosphorylation and nuclear translocation of Transcription Factor EB (TFEB), a key transcriptional re...
ORGANISM(S): Homo sapiens (Human) 
2018-10-18 | PXD009677 | Pride
Glucose lysosome biogenesis running header: tfeb nuclear export Gsk3 Tfeb Nuclear export signal Mtor 
GenomicsCancer -associated mutations in XPO1 transform cells through altered nuclear export signal recognition
Cancer -associated mutations in XPO1 transform cells through altered nuclear export signal recognition
PRJNA492253 | ENA
GenomicsA germline ETV6 mutation disrupts hematopoiesis via de novo creation of a nuclear export signal
A germline ETV6 mutation disrupts hematopoiesis via de novo creation of a nuclear export signal
PRJNA1214692 | ENA
GenomicsA germline ETV6 mutation disrupts hematopoiesis via de novo creation of a nuclear export signal
A germline ETV6 mutation disrupts hematopoiesis via de novo creation of a nuclear export signal
PRJNA1216382 | ENA
ProteomicsATM INDUCES MACROD2 NUCLEAR EXPORT UPON DNA DAMAGE
ADP-ribosylation is a dynamic post-translation modification that regulates the early phase of various DNA repair pathways by recruiting repair factors to chromatin. ADP-ribosylation levels are defined by the activities of transferases and hydrolases. Little is known about regulation of these enzymes...
ORGANISM(S): Homo sapiens (Human) 
2016-10-12 | PXD003712 | Pride
Atm phosphorylation Dna damage Nuclear export Regulation of adp-ribosylation 
ProteomicsBRAF/MAPK and GSK3b signalling signaling converge to control MITF nuclear export
The close integration of the MAPK, PI3K and WNT signaling pathways underpins much of development and is deregulated in cancer. In principle, combinatorial post-translational modification of key lineage–specific transcription factors would be an effective means to integrate critical signaling events....
ORGANISM(S): Mus musculus (Mouse) 
2022-02-28 | PXD010665 | Pride
Mitf | melanoma | mapk | nuclear export | gsk3b 
UnknownFAK nuclear export signal sequences.
Not available
S-EPMC2547126 | biostudies-literature
UnknownA supraphysiological nuclear export signal is required for parvovirus nuclear export.
Not available
S-EPMC2397317 | biostudies-literature
TranscriptomicsTranscription profiling of human peripheral T cells responding to stimulation of antigen-specific T cell receptor and CD28
Optimal activation of T cells requires effective occupancy of both the antigen-specific T cell receptor and a second coreceptor such as CD28. We used cDNA microarrays to characterize the genomic expression program in human peripheral T cells responding to stimulation of these receptors. We found tha...
ORGANISM(S): Homo sapiens 
2005-09-23 | E-SMDB-748 | biostudies-arrayexpress
TranscriptomicsCancer -associated mutations in XPO1 transform cells through altered nuclear export signal recognition
Proper nucleocytoplasmic distribution of proteins is essential to cellular homeostasis but what role the altered nuclear export machinery commonly described in cancer cells plays in cancer initiation is not known. Here, genomic analysis of 42,793 cancers identified recurrent mutational hotspots in X...
ORGANISM(S): Homo sapiens Mus musculus 
2021-09-01 | GSE120231 | GEO
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