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TranscriptomicsElucidating the role of polygalacturonase genes in strawberry fruit softening
The aim of this study was to determine the role of genes encoding polygalacturonases in strawberry fruit softening. To this purpose, several transgenic lines, cv. Chandler, were generated: plants with PG genes FaPG1 or FaPG2 downregulated, alone or in combination, by antisense transformation. Plants...
ORGANISM(S): Fragaria x ananassa 
2021-01-21 | E-MTAB-8736 | biostudies-arrayexpress
Proteomics2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction
Mitochondria play a crucial role in regulating cellular homeostasis in response to intrinsic and extrinsic cues by changing cellular metabolism to meet these challenges. However, the molecular underpinnings of this regulation and the complete spectrum of these physiological outcomes remain largely u...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-26 | PXD064288 | Pride
Nuclear softening Brown adipose tissue Mitochondria 2-hydroxyglutarate 
Genomics2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction
2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction
PRJNA1130460 | ENA
GenomicsPIP4K2B is mechanoresponsive and controls heterochromatin-driven nuclear softening through UHRF1
PIP4K2B is mechanoresponsive and controls heterochromatin-driven nuclear softening through UHRF1
PRJNA823674 | ENA
Genomics2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction II
2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction II
PRJNA1130988 | ENA
UnknownNuclear softening mediated by Sun2 suppression delays mechanical stress-induced cellular senescence.
Not available
S-EPMC10192198 | biostudies-literature
Transcriptomics2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction
This study reports accumulation of larger lipid droplets in an adipocyte specific manner upon loss of CLPP. The mitochondria in KO BAT have mild respiratory chain deficiency but no difference in respiratory output at tissue and cellular level. Omics analysis reveals that loss of CLPP leads to tissue...
ORGANISM(S): Mus musculus 
2025-05-22 | GSE271207 | GEO
UnknownNuclear softening expedites interstitial cell migration in fibrous networks and dense connective tissues.
Not available
S-EPMC7304973 | biostudies-literature
Transcriptomics2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction II
This study reports accumulation of larger lipid droplets in an adipocyte specific manner upon loss of CLPP. The mitochondria in KO BAT have mild respiratory chain deficiency but no difference in respiratory output at tissue and cellular level. Omics analysis reveals that loss of CLPP leads to tissue...
ORGANISM(S): Mus musculus 
2025-05-22 | GSE271358 | GEO
Genomics2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction
2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction
PRJNA1259937 | ENA
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