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TranscriptomicsRNA-Seq of SARS-CoV-2 Nucleocapsid protein expression in human embryonic kidney cell line HEK293
The RNA genome of the SARS-CoV-2 virus encodes for four structural proteins, 16 non-structural proteins and nine putative accessory factors. A high throughput analysis of interactions between human and SARS-CoV-2 proteins identified multiple interactions of the structural Nucleocapsid (N) protein wi...
ORGANISM(S): Homo sapiens 
2024-09-16 | E-MTAB-14342 | biostudies-arrayexpress
ProteomicsA hybrid structural determination approach to investigate protein-RNA complexes of the nucleocapsid protein of SARS-CoV-2
UV-light-induced protein-RNA cross-linking followed by MS analysis was used to identify the interaction sites between the N-terminal (NTD) or C-terminal domain (CTD) of the SARS-CoV-2 nucleocapsid protein and the s2m element of the viral RNA.
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2023-03-13 | PXD037438 | Pride
Nucleocapsid Protein-rna cross-linking Uv cross-linking Protein-rna complexes Sars-cov-2 
ProteomicsProteomic identification of recombinant nucleocapsid N protein 40 kDa fragment from SARS-CoV-2
Serological testing is important methodfor diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Nucleocapsid (N) protein is the most abundant virus derived protein and strong immunogen. We aimed to find its efficient, low-cost production. SARS-CoV-2 ...
ORGANISM(S): SARS coronavirus Sin3765V 
2021-02-17 | PXD023341 | Pride
N protein fragment Covid-19 Prokaryotic expression serological assay Recombinant nucleocapsid protein Sars-cov-2 
ProteomicsThe analysis of PRRSV nucleocapsid interactome
The porcine reproductive and respiratory virus (PRRSV) is a significant swine disease, causing reproductive failure in sows and complex respiratory failure in sows and complex repiratory syndrome in pigs of all ages. PRRSV is an enveloped +ssRNA virus classified within the family Arteriviridae, whic...
ORGANISM(S): Homo sapiens (Human) 
2026-05-01 | PXD044394 | Pride
Prrsv nidovirus arterivirus nucleocapsid interactome 
ProteomicsArginine Methylation Regulates SARS-CoV-2 Nucleocapsid Protein Function and Viral Replication
Viral proteins are known to be methylated by host protein arginine methyltransferases (PRMTs) playing critical roles during viral infections. Herein, we show that PRMT1 methylates SARS-CoV-2 nucleocapsid (N) protein at residues R95 and R177 within RGG/RG sequences. Arginine methylation of N protein ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025763 | Pride
Prmt1 Sars-cov-2 Rna binding Stress granules Nucleocapsid (n) protein Arginine methylation Type i prmt inhibitor Condensate Rgg/rg motif 
ProteomicsAffinity Purification Mass Spectrometry Analysis of Mutant and Wildtype SARS-CoV-2 Nucleocapsid Protein
The COVID-19 pandemic is arguably the most important global threat to humankind that the world has seen in a century. SARS-CoV-2 has now reached 196 countries across all continents with over 159 million confirmed cases with 3.3 million deaths todate. Currently, our knowledge on how and why SARS-CoV-...
ORGANISM(S): Homo sapiens (Human) 
2021-12-02 | PXD027168 | Pride
Covid-19 Nucleocapsid protein Sars-cov-2 Data dependent acqusition (dda) Lc-ms/ms 
ProteomicsSARS-CoV-2 Nucleocapsid protein Native Top-down
Native top-down analysis via ETnoD and HCD on the Orbitrap Eclipse of SARS-CoV-2 nucleocapsid (N) protein heterologously expressed in E. coli
ORGANISM(S): E. Coli 
2021-05-09 | MSV000087391 | MassIVE
ProteomicsLC-MSMSMass Spectrometric detection of SARS-CoV-2 virus in scrapings of the epithelium of the nasopharynx of infected patients via Nucleocapsid N protein
Detection of viral RNA by PCR is currently the main diagnostic tool for COVID-191. The PCR-based test, however, shows limited sensitivity, especially at early and late stages of the disease development, and is relatively time consuming. Fast and reliable complementary methods for detecting the viral...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2020-08-14 | PXD019648 | Pride
Covid Covid-19 Proteomics Sars-cov-2 
ProteomicsTargeted Detection of SARS-CoV-2 Protein Variants by Mass Spectrometry
COVID-19 vaccines are continuing to become more widely available, but accurate and rapid testing remains a crucial tool for slowing the spread of the SARS-CoV-2 virus. Although quantitative reverse transcription-polymerase chain reaction (qRT-PCR) remains the most prevalent testing methodology, nume...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026795 | Pride
Nucleocapsid Sars-cov-2 Single amino acid protein variants Tandem mass spectrometry 
ProteomicsStimulus-specific Immune Modulation by SARS-CoV-2 Nucleocapsid Correlates with Severe COVID-19
A significant proportion of patients with COVID-19 disease, caused by SARS-CoV-2, develop acute respiratory distress syndrome characterized by pro-inflammatory cytokine secretion and dampened IFN-mediated antiviral response. To uncover the mechanisms by which SARS-CoV-2 drives this dysregulation, we...
ORGANISM(S): Homo sapiens (Human) Severe acute respiratory syndrome coronavirus 2 
2026-06-25 | PXD067631 | Pride
Sars-cov-2 Macrophages Nf-kb pathways Nucleocapsid (n) Pro-inflammatory responses 
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