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Rotational settings quantize nucleosome movement by chromatin regulators
Histone octamers are thought to be a rigid part of nucleosomes that shape chromatin and block cellular machinery from accessing DNA. ATP-dependent chromatin remodelers like ISW2 mobilize nucleosomes to provide DNA access. We find evidence for histone octamer distortion preceding DNA being moved into...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2020-05-27 | PXD013967 | Pride
Proper nucleosome positioning is essential for gene regulation and genomic integrity. The need for nucleosomes to be assembled throughout the genome has to be balanced with known intrinsic sequence preferences of nucleosomes. Current models posit that chromatin regulators override the intrinsic pref...
ORGANISM(S): Mus musculus 
2025-12-22 | GSE314045 | GEO
Spt4 helps RNAPII pass the +2 nucleosome barrier in vivo
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