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TranscriptomicsTranscriptional effect of an off-target shRNA targeting nucleostemin in human glioblastoma-derived cancer stem cells
Glioblastomas (GBM) may contain a variable proportion of active cancer stem cells (CSCs) capable of self-renewal, of aggregating into CD133+ neurospheres, and to develop intracranial tumors that phenocopy the original ones. We hypothesized that nucleostemin may contribute to cancer stem cell biology...
ORGANISM(S): Homo sapiens 
2011-10-20 | E-GEOD-30448 | biostudies-arrayexpress
TranscriptomicsThe forced expression of Nanog or Esrrb allows preserve ESC status in the absence of nucleostemin expression
Nucleostemin (NS) gene is known to be expressed in stem cells in general including embryonic stem cells (ESCs). Previous knockdown and knockout studies have demonstrated that NS is important for the preservation of their self-renewality and high levels of pluripotent marker gene expression in mouse ...
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-56797 | biostudies-arrayexpress
TranscriptomicsAssociation of prognosis of acute myeloid leukemia patients with leukemia stem cell gene signature based on nucleostemin promoter activity
Acute myeloid leukemia (AML) is a heterogeneous neoplastic disorder, in which only a subset of cells have function as leukemia-initiating cells (LICs). In this study, we prospectively evaluated leukemia-initiating capacity of fractionated subpopulations of AML cells depending on expression of a nucl...
ORGANISM(S): Mus musculus 
2014-07-30 | E-GEOD-58032 | biostudies-arrayexpress
ProteomicsProteomics investigation of Nucleostemin role in Nucleo-phosmin mutated OCI-AML 3 cell line
Nucleostemin (NS; product of the GNL3 gene) is a nucleolar/nucleoplasm shuttling GTPase whose levels are high in stem cells while rapidly decreasing upon differentiation. NS levels are also high in several solid and hematological neoplasms, including acute myeloid leukemia (AML). While a role in tel...
ORGANISM(S): Homo sapiens (Human) 
2022-08-11 | PXD034012 | Pride
Nucleophosmin Nucleostemin Shotgun proteomics Acute myeloid leukemia 
UnknownMultiple controls regulate nucleostemin partitioning between nucleolus and nucleoplasm.
Not available
S-EPMC2997529 | biostudies-literature
GenomicsGNL3/nucleostemin links DNA replication homeostasis and replication forks stability
GNL3/nucleostemin links DNA replication homeostasis and replication forks stability
PRJNA749783 | ENA
Genomics
Nucleostemin promotes CRC cancer cells metastasis
PRJNA680664 | ENA
UnknownNucleophosmin is a binding partner of nucleostemin in human osteosarcoma cells.
Not available
S-EPMC2441661 | biostudies-literature
UnknownNucleoplasmic mobilization of nucleostemin stabilizes MDM2 and promotes G2-M progression and cell survival.
Not available
S-EPMC5048913 | biostudies-literature
TranscriptomicsTranscriptional effect of an off-target shRNA targeting nucleostemin in human glioblastoma-derived cancer stem cells
Glioblastomas (GBM) may contain a variable proportion of active cancer stem cells (CSCs) capable of self-renewal, of aggregating into CD133+ neurospheres, and to develop intracranial tumors that phenocopy the original ones. We hypothesized that nucleostemin may contribute to cancer stem cell biology...
ORGANISM(S): Homo sapiens 
2011-10-21 | GSE30448 | GEO
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