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TranscriptomicsMiR-192 inhibits nucleotide excision repair by targeting ERCC3 and ERCC4 in HepG2.2.15 cells.
Deficient DNA repair capacity is associated with genetic lesions accumulation and susceptibility to carcinogenesis. MicroRNAs (miRNAs) are small non-coding RNAs that regulate various cellular pathways including DNA repair. Here we hypothesized that the existence of HBV products may interfere with ce...
ORGANISM(S): Homo sapiens 
2011-08-02 | E-GEOD-27561 | biostudies-arrayexpress
TranscriptomicsDNA repair and recovery of RNA synthesis following exposure to ultraviolet light are delayed in long genes
The kinetics of DNA repair and RNA synthesis recovery in human cells following UV-irradiation were assessed using nascent RNA Bru-seq and quantitative long PCR. It was found that UV light inhibited transcription elongation and that recovery of RNA synthesis occurred as a wave in the 5’-3’ direction ...
ORGANISM(S): Homo sapiens 
2015-03-03 | E-GEOD-65985 | biostudies-arrayexpress
TranscriptomicsExpression changes in Caenorhabditis elegans xpa-1 mutant
Background: The ability of an organism to repair DNA damage is implicated in carcinogenesis and aging. Interestingly expression profiling of Nucleotide Excision Repair (NER) deficient segmental progeroid mice revealed gene expression changes resembling these observed in aged wild type animals. Our p...
ORGANISM(S): Caenorhabditis elegans 
2013-05-03 | E-GEOD-39252 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from Csbm/m/Xpa-/- knockout mice to investigate the effect of nucleotide excision repair pathway inactivation
Cockayne syndrome (CS) is a photosensitive, DNA repair disorder associated with progeria caused by a defect in the transcription-coupled repair (TCR) subpathway of nucleotide excision repair (NER). Here, complete inactivation of NER in Csbm/m/Xpa-/- mutants causes a phenotype that reliably mimics th...
ORGANISM(S): Mus musculus 
2007-01-01 | E-MEXP-835 | biostudies-arrayexpress
TranscriptomicsRoles for the Transcription Elongation Factor NusA in Both DNA Repair and Damage Tolerance Pathways in Escherichia coli
Here we report our observations that have led us to propose that the transcription elongation factor NusA promotes a novel class of transcription-coupled repair (TCR) in addition to its previously proposed role in recruiting translesion synthesis (TLS) DNA polymerases to gaps encountered during tran...
ORGANISM(S): Escherichia coli 
2010-07-14 | E-GEOD-22829 | biostudies-arrayexpress
GenomicsThe yeast GG-NER complex evicts histone H2A.Z-containing barrier nucleosomes from CID boundaries during DNA repair
Background: Repair of DNA damage requires chromatin remodeling to permit removal of the lesions. How nucleosomes are remodelled to initiate repair of DNA damage remains largely unknown. Here, we describe how chromatin is altered during repair of UV-induced DNA damage at the level of the linear organ...
ORGANISM(S): Saccharomyces cerevisiae 
2018-12-06 | E-MTAB-6569 | biostudies-arrayexpress
TranscriptomicsGlobal Genome-Nucleotide Excision Repair is Organised into Domains Promoting Efficient DNA Repair in Chromatin
The rates at which lesions are removed by DNA repair can vary widely throughout the genome with important implications for genomic stability. We measured the distribution of nucleotide excision repair (NER) rates for UV induced lesions throughout the yeast genome. By plotting these repair rates in r...
ORGANISM(S): Saccharomyces cerevisiae 
2016-07-21 | E-MTAB-4641 | biostudies-arrayexpress
ProteomicsStructure of TFIIH/Rad4-Rad23-Rad33 in damaged DNA opening in Nucleotide Excision Repair
TFIIH is a 10-protein complex that is conserved throughout eukaryotes. TFIIH has two primary cellular functions: transcription initiation and nucleotide excision repair (NER). NER in eukaryotes begins by recognition of a bulky lesion by the obligate dimer Rad4-Rad23. This is followed closely by the ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-07-07 | PXD021212 | Pride
Dna repair Tfiih Rad4 Rad33 Rad23 Dna damage Nucleotide excision repair 
ProteomicsA disease-associated XPA allele interferes with TFIIH binding and primarily affects the transcription-coupled sub-pathway of nucleotide excision repair
XPA is a central scaffold protein in nucleotide excision repair (NER) that interacts with and coordinates the assembly of repair complexes. Inactivating mutations in XPA causes Xeroderma Pigmentosum (XP), which is characterized by extreme UV sensitivity and a highly elevated skin cancer risk. Here, ...
ORGANISM(S): Homo sapiens (Human) 
2023-02-19 | PXD033520 | Pride
Nucleotide excision repair  xeroderma pigmentosum 
ProteomicsStructural basis of TFIIH activation for nucleotide excision repair
Nucleotide excision repair (NER) is the major DNA repair pathway that removes UV-induced and bulky DNA lesions. There is currently no structure of NER intermediates, which form around the large multisubunit transcription factor IIH (TFIIH). Here we report the cryo-EM structure of an NER intermediate...
ORGANISM(S): Homo sapiens (Human) 
2019-07-02 | PXD013947 | Pride
Ner pathway Bs3 cross-linking 
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