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ProteomicsLEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation
Quantitative crosslinking analysis to probe in vitro conformational dynamics governing ESCRT-mediated nuclear envelope formation. CHMP7 was crosslinked with D12-BS3 while CHMP7 in the presence of LEM2 winged helix domain was crosslinked with H12-BS3. Samples were mixed after crosslinking and analy...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-01-24 | MSV000084837 | MassIVE
UnknownPhase separation drives heterochromatin domain formation.
Not available
S-EPMC6022742 | biostudies-literature
ProteomicsCompartment resolved reference map from highly purified naive, activated, effector and memory CD8+ cells
Differentiation of CD8+ T lymphocytes into effector and memory cells is key for an adequate immune response and relies on complex interplay of pathways that convey signals from cell surface to nucleus. In this study, we fractionated four CD8+ T cell subtypes; naïve, recently activated effector, eff...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2016-02-29 | MSV000079540 | MassIVE
UnknownGranulins modulate liquid-liquid phase separation and aggregation of the prion-like C-terminal domain of the neurodegeneration-associated protein TDP-43.
Not available
S-EPMC7039568 | biostudies-literature
Unknown8q24 derived ZNF252P promotes tumorigenesis by driving phase separation to activate c-Myc mediated feedback loop.
Not available
S-EPMC11865308 | biostudies-literature
UnknownSubcellular Localization of Seed-Expressed LEA_4 Proteins Reveals Liquid-Liquid Phase Separation for LEA9 and for LEA48 Homo- and LEA42-LEA48 Heterodimers.
Not available
S-EPMC8698616 | biostudies-literature
TranscriptomicsRNA sequencing of iPSC and Human dermal fibroblasts
RNA sequencing of iPSC and Human dermal fibroblasts, total RNA and fractionated into nuclear, cytoplasmic and chromatin fractions.
ORGANISM(S): Homo sapiens 
2021-04-28 | E-MTAB-10383 | biostudies-arrayexpress
TranscriptomicsCAGE sequencing of iPSC and Human dermal fibroblasts
CAGE sequencing of iPSC and Human dermal fibroblasts, total RNA and fractionated into nuclear, cytoplasmic and chromatin fractions.
ORGANISM(S): Homo sapiens 
2021-04-28 | E-MTAB-10384 | biostudies-arrayexpress
MetabolomicsTFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFAM-knockdown HCC cells when cytoske...
2022-06-23 | MTBLS4307 | MetaboLights
ProteomicsSubcellular Relocalization of Proteins in Response to Cisplatin-Induced DNA Damage
Cells regulate the intracellular localization of proteins to adapt to different environmental conditions including DNA damage, but this form of regulation has not been analyzed systematically. The aim of this study was to investigate the protein distribution between nucleus and cytoplasm in response...
ORGANISM(S): Homo sapiens (Human) 
2024-05-29 | PXD019642 | Pride
Ovarian cancer Subcellular proteomics Cisplatin 
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