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ProteomicsAn Amphipathic Helix in Brl1 is Required for Nuclear Pore Complex Biogenesis in S. cerevisiae - KARMA analysis of Nup170 with/without Brl1 degradation (DIA)
This project was aimed at investigating nuclear pore complex biogenesis upon inducible degradation of Brl1 using the Kinetic Analysis of incorporation Rates in Macromolecular Assemblies (KARMA, Onischenko et al. 2020) method. In brief, the nuclear pore complex was purified through endogenously tagge...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-08-17 | PXD032024 | Pride
Dia Karma 
GenomicsThe nucleoporin Nup170p is required for subtelomeric chromatin structure and gene silencing. [MNase-Seq]
Transcriptionally silent heterochromatin preferentially localizes at the nuclear periphery, but, despite this, certain budding yeast genes relocate to the nuclear periphery following gene activation, implicating the nuclear envelope in both transcriptional activation and silencing. It is unclear how...
ORGANISM(S): Saccharomyces cerevisiae 
2013-02-28 | E-GEOD-36792 | biostudies-arrayexpress
ProteomicsAn Amphipathic Helix in Brl1 is Required for Nuclear Pore Complex Biogenesis in S. cerevisiae - Lysate intermixing text (DIA)
The project was aimed at assessing the dynamic protein exchange of the nuclear pore complex during the affinity purification procedure with Brl1 and Nup170 bait. In brief, equal fractions of an affinity tagged strain grown in unlabeled medium and a wild-type culture grown in metabolically labeled me...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-08-17 | PXD032034 | Pride
Dia 
Genomics
Regulation of PCNA levels on DNA by Nup170 in Saccharomyces cerevisiae
PRJNA917682 | ENA
ProteomicsNuclear pore complexes mediate subtelomeric gene silencing by regulating PCNA levels on chro atin
The nuclear pore complex (NPC) physically interacts with chromatin and regulates gene expression. The Saccharomyces cerevisiae inner ring nucleoporin Nup170 has been implicated in chromatin organization and the maintenance of gene silencing in subtelomeric regions. To gain insight into how Nup170 re...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-06-13 | PXD041496 | Pride
Nuclear pore complex Subtelomeric gene silencing Nup170 Nucleoporin Ctf18-rfc Pcna 
UnknownNuclear pore complexes mediate subtelomeric gene silencing by regulating PCNA levels on chromatin.
Not available
S-EPMC10292210 | biostudies-literature
UnknownNup154, a new Drosophila gene essential for male and female gametogenesis is related to the nup155 vertebrate nucleoporin gene.
Not available
S-EPMC2149350 | biostudies-literature
UnknownPossible Molecular Markers for the Diagnosis of Pancreatic Ductal Adenocarcinoma.
Not available
S-EPMC5928849 | biostudies-literature
GenomicsThe nucleoporin Nup170p is required for subtelomeric chromatin structure and gene silencing. [MNase-Seq]
Transcriptionally silent heterochromatin preferentially localizes at the nuclear periphery, but, despite this, certain budding yeast genes relocate to the nuclear periphery following gene activation, implicating the nuclear envelope in both transcriptional activation and silencing. It is unclear how...
ORGANISM(S): Saccharomyces cerevisiae 
2013-02-28 | GSE36792 | GEO
UnknownYeast silencing factor Sir4 and a subset of nucleoporins form a complex distinct from nuclear pore complexes.
Not available
S-EPMC5626528 | biostudies-literature
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